PRC1 SUMOylates CTBP1 with SUMO1

Stable Identifier
R-HSA-3108209
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CBX4 (Pc2) via its SUMO-interacting motifs recruits both CTBP1 and SUMO1:UBE2I (SUMO1:UBC9) to polycomb bodies where CTBP1 is SUMOylated with SUMO1 at lysine-428 (Kagey et al. 2003, Merrill et al. 2010, Yang and Sharrocks 2010).
Literature References
PubMed ID Title Journal Year
20176810 The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motif

Yang, SH, Sharrocks, AD

Mol. Cell. Biol. 2010
12679040 The polycomb protein Pc2 is a SUMO E3

Melhuish, TA, Wotton, D, Kagey, MH

Cell 2003
20098713 A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity

Yang, SH, Melhuish, TA, Merrill, JC, Sharrocks, AD, Wotton, D, Kagey, MH

PLoS ONE 2010
Participants
Participates
Catalyst Activity

SUMO transferase activity of PRC1 complex [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!