Reactome | ZEB2 [nucleoplasm]

ZEB2 [nucleoplasm]

Stable Identifier

R-HSA-3108222

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Zinc finger E-box-binding homeobox 2, ZEB2_HUMAN, SMAD-interacting protein 1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O60315 ZEB2

Gene Names

ZEB2, KIAA0569, SIP1, ZFHX1B, ZFX1B, HRIHFB2411

Chain

chain:1-1214

Reference Genes

BioGPS Gene:9839 ZEB2

COSMIC (genes):ZEB2 ZEB2

CTD Gene:9839 ZEB2

dbSNP Gene:9839 ZEB2

ENSEMBL:ENSG00000169554 ZEB2

HGNC:14881 ZEB2

KEGG:hsa:9839 ZEB2

Monarch:9839 ZEB2

NCBI Gene:9839 ZEB2

OMIM:605802 ZEB2

UCSC:O60315 ZEB2

Reference Transcript

Other Identifiers

11747942_a_at

11756954_s_at

17117888

203603_PM_s_at

203603_s_at

228333_PM_at

228333_at

233031_PM_at

233031_at

235593_PM_at

235593_at

240652_PM_at

240652_at

2579558

2579567

2579568

2579569

2579571

2579573

2579574

2579575

2579576

2579577

2579583

2579584

2579586

2579587

2579588

2579589

2579590

2579591

2579592

2579605

2579606

2579607

2579608

2579609

2579610

2579611

2579612

2579614

2579615

2579629

2579631

2579632

2579633

2579634

2579635

2579636

2579637

2579638

2579639

2579640

2579652

2579655

2579674

2579675

2579676

2579677

2579678

2579680

2579681

2579682

2579683

2579684

2579685

2579686

2579687

2579688

2579689

2579690

2579691

2579692

2579693

2579694

2579695

2579696

2579697

2579698

2579699

2579700

2579701

2579702

2579703

2579704

2579705

2579706

2579707

2579708

2579709

2579721

2762052

2762054

2762055

35681_r_at

46653_at

59245_at

70325_at

73495_at

8055624

8055639

9839

ADDON000691.hg

ADDON001322.hg

A_21_P0000590

A_21_P0014838

A_23_P142560

A_23_P407203

A_24_P102283

A_24_P367454

A_33_P3243832

GE53282

GE756584

GE759775

GO:0000122

GO:0000785

GO:0000978

GO:0000981

GO:0001227

GO:0001935

GO:0003013

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005829

GO:0006355

GO:0006357

GO:0007010

GO:0007399

GO:0010764

GO:0012501

GO:0019208

GO:0030154

GO:0030511

GO:0036446

GO:0043149

GO:0043226

GO:0043542

GO:0045636

GO:0045892

GO:0045944

GO:0046872

GO:0048023

GO:0048066

GO:0048143

GO:0048856

GO:0048870

GO:0070269

GO:0072537

GO:0090263

GO:0090649

GO:0097324

GO:0098772

GO:0140110

GO:1903056

GO:1904330

GO:1904520

GO:1905603

HMNXSV003016155

HMNXSV003017840

HMNXSV003018281

HMNXSV003040953

HMNXSV003053991

Hs.114103.0.A1_3p_at

Hs.15069.0.A1_3p_at

Hs.283930.0.S1_3p_at

Hs.283930.0.S1_3p_x_at

Hs.293676.0.A1_3p_at

ILMN_1688698

ILMN_1817518

PH_hs_0028851

TC02004620.hg

TC02004621.hg

TC02004623.hg

g7662183_3p_s_at

p26095

p27386

p27387

p27388

Participates

as an output of

Expression of ZEB2 in neural plate (Homo sapiens)

as a component of

ZEB2:SP1 [nucleoplasm] (Homo sapiens)

as an input of

ZEB2 binds SP1 (Homo sapiens)

This entity regulates

Positively

Inferred To

ZEB2 [nucleoplasm] (Bos taurus)

ZEB2 [nucleoplasm] (Canis familiaris)

zeb2b [nucleoplasm] (Danio rerio)

zfh1 [nucleoplasm] (Drosophila melanogaster)

Sip1 [nucleoplasm] (Gallus gallus)

Zeb2 [nucleoplasm] (Mus musculus)

Zeb2 [nucleoplasm] (Rattus norvegicus)

zag-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

XP_006712944.1, NP_001165124.1, XP_006712945.1, NP_055610.1

ENSEMBL

ENST00000627532, ENSP00000386854, ENSP00000454157, ENSP00000487174, ENST00000409487, ENST00000539609, ENSP00000443792, ENST00000558170

OpenTargets

ENSG00000169554

HPA

ENSG00000169554-ZEB2

PRO

O60315

Pharos - Targets

O60315

Orphanet

ZEB2

PDB

2DA7

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.802	9
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.643	10
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.612	12
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.597	5
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.577	6
UniProt:O94776 MTA2	1	MTA2 [nucleoplasm] (R-HSA-4657009)	0.577	4
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.553	2
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.527	3
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.462	5