Reactome | polySUMO2,3-K428-CTBP1 [nucleoplasm]

polySUMO2,3-K428-CTBP1 [nucleoplasm]

Stable Identifier

R-HSA-3108226

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SUMO2,3 N-glycyl-lys428 CTBP1, C-terminal-binding protein 1, CTBP1_HUMAN, CtBP

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Literature References

PubMed ID	Title	Journal	Year
20176810	The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motif Yang, SH, Sharrocks, AD	Mol. Cell. Biol.	2010
20098713	A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity Yang, SH, Melhuish, TA, Merrill, JC, Sharrocks, AD, Wotton, D, Kagey, MH	PLoS ONE	2010

External Reference Information

External Reference

UniProt:Q13363 CTBP1

Gene Names

CTBP1, CTBP

Chain

chain:1-440

Reference Genes

BioGPS Gene:1487 CTBP1

COSMIC (genes):CTBP1 CTBP1

CTD Gene:1487 CTBP1

dbSNP Gene:1487 CTBP1

ENSEMBL:ENSG00000159692 CTBP1

HGNC:2494 CTBP1

KEGG:hsa:1487 CTBP1

Monarch:1487 CTBP1

NCBI Gene:1487 CTBP1

OMIM:602618 CTBP1

UCSC:Q13363 CTBP1

Reference Transcript

Participates

as an output of

PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)

Other forms of this molecule

CTBP1 [nucleoplasm]

monoSUMO1-K428-CTBP1 [nucleoplasm]

Inferred To

polySUMO2,3-K428-CTBP1 [nucleoplasm] (Drosophila melanogaster)

polySUMO2,3-K428-CTBP1 [nucleoplasm] (Mus musculus)

polySUMO2,3-K428-CTBP1 [nucleoplasm] (Rattus norvegicus)

wu:fa96d06 [nucleoplasm] (Danio rerio)

CTBP1 [nucleoplasm] (Bos taurus)

CTBP1 [nucleoplasm] (Gallus gallus)

CTBP1 [nucleoplasm] (Sus scrofa)

ctbp1 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 428

Coordinate

428

Modification

polySUMO2,3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

OpenTargets

ENSG00000159692

ENSEMBL

ENST00000703138, ENSG00000159692, ENSP00000372411, ENST00000703163, ENSP00000290921, ENST00000290921, ENST00000382952, ENSP00000515195, ENSP00000515211

GeneCards

CTBP1

HPA

ENSG00000159692-CTBP1

PRO

Q13363

Pharos - Targets

Q13363

GlyGen

Q13363

Orphanet

CTBP1

HMDB Protein

HMDBP02216

PDB

6CDF, 4U6S, 1MX3, 6V8A, 6V89, 6CDR, 4LCE, 7KWM, 4U6Q, 8ARI

Interactors (60)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P56545 CTBP2	1	CTBP2 [nucleoplasm] (R-HSA-5333990)	0.918	17
UniProt:Q92618 ZN516			0.884	16
UniProt:Q96JN0 LCOR			0.878	11
UniProt:P37275 ZEB1	1	ZEB1 [nucleoplasm] (R-HSA-6789836)	0.859	12
UniProt:O75362 ZNF217	1	ZNF217 [nucleoplasm] (R-HSA-9011738)	0.848	11
UniProt:Q8N3X6 LCORL			0.837	7
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.802	6
UniProt:O60315 ZEB2	1	ZEB2 [nucleoplasm] (R-HSA-3108222)	0.802	9
UniProt:Q9UKL0 RCOR1	1	RCOR1 [nucleoplasm] (R-HSA-996766)	0.788	11
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.788	7
UniProt:O95785 WIZ			0.774	8
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.748	8
UniProt:Q99592 ZBT18			0.744	7
UniProt:Q9H6R7 WDCP	2	WDCP(1-680)-p-7Y-ALK(1061-1620) fusion [cytosol] (R-HSA-9700468) WDCP(1-680)-ALK(1061-1620) fusion [cytosol] (R-HSA-9700460)	0.725	7
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.725	8
UniProt:Q96EK4 THA11			0.716	4
UniProt:Q9UHF7 TRPS1			0.706	4
UniProt:O00257 CBX4	2	monoSUMO1-K494-CBX4 [nucleoplasm] (R-HSA-4551626) CBX4 [nucleoplasm] (R-HSA-389118)	0.695	5
UniProt:Q99708 RBBP8	4	p-S327,T847,T859-RBBP8 [nucleoplasm] (R-HSA-5684138) Ac-K-RBBP8 [nucleoplasm] (R-HSA-5685955) RBBP8 [nucleoplasm] (R-HSA-912399) p-S327,T847-RBBP8 [nucleoplasm] (R-HSA-5684083)	0.691	4
UniProt:P48552 NRIP1	2	NRIP1 [nucleoplasm] (R-HSA-4086031) monoSUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057)	0.683	3
UniProt:Q96PK6 RBM14	1	RBM14 [nucleoplasm] (R-HSA-8938345)	0.643	4
UniProt:Q96MY1 NOL4L			0.643	6
UniProt:Q9H9B1 EHMT1	1	EHMT1 [nucleoplasm] (R-HSA-1183226)	0.643	5
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.643	3
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.643	9
UniProt:Q8N895 ZN366			0.633	5
UniProt:Q9HAZ2 PRDM16	2	PRDM16 [nucleoplasm] (R-HSA-3222269) PRDM16 [cytosol] (R-HSA-5634812)	0.615	3
UniProt:Q5H9F3 BCORL			0.615	3
UniProt:Q03112 MECOM	2	MECOM [nucleoplasm] (R-HSA-8943897) MECOM [cytosol] (R-HSA-5634790)	0.615	3
UniProt:Q13029 PRDM2			0.615	3
UniProt:O94818 NOL4			0.615	3
UniProt:Q9Y5P3 RAI2			0.594	3
UniProt:P03255 E1A			0.593	3
UniProt:Q14526 HIC1	2	monoSUMO1-K333-HIC1 [nucleoplasm] (R-HSA-4090368) HIC1 [nucleoplasm] (R-HSA-4090364)	0.573	2
UniProt:Q6W2J9 BCOR			0.569	3
UniProt:O15409 FOXP2			0.553	2
UniProt:Q96JN0-2 LCOR			0.547	2
UniProt:A7XYQ1 SOBP			0.547	2
UniProt:Q69140 EBNA6			0.544	2
UniProt:P67870 CSNK2B	5	CSNK2B [cytosol] (R-HSA-201693) CSNK2B [nucleoplasm] (R-HSA-6805067) CSNK2B [ficolin-1-rich granule lumen] (R-HSA-6801290) CSNK2B [extracellular region] (R-HSA-6806508) CSNK2B [secretory granule lumen] (R-HSA-6801319)	0.527	2
UniProt:Q8IZ40 RCOR2			0.527	2
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.527	2
UniProt:Q5JU69 TOR2A			0.527	2
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.527	2
UniProt:P08833 IGFBP1	3	p-IGFBP1 [endoplasmic reticulum lumen] (R-HSA-8957029) IGFBP1 [endoplasmic reticulum lumen] (R-HSA-8956699) IGFBP1 [extracellular region] (R-HSA-381513)	0.527	2
UniProt:Q96JB3 HIC2			0.527	2
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.527	4
UniProt:Q9P2K3 RCOR3			0.527	3
UniProt:P28749 RBL1	2	RBL1 [nucleoplasm] (R-HSA-389104) p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085)	0.527	2
UniProt:O43474 KLF4	1	KLF4 [nucleoplasm] (R-HSA-434463)	0.524	4
UniProt:P57682 KLF3			0.519	2
UniProt:Q9Y4X4 KLF12			0.519	2
UniProt:Q9BXL5 HEMGN			0.508	2
UniProt:Q9NYB0 TERF2IP	1	TERF2IP [nucleoplasm] (R-HSA-174873)	0.508	2
UniProt:Q15583 TGIF1	1	TGIF1 [nucleoplasm] (R-HSA-2186594)	0.508	2
UniProt:A2APF7 A2APF7			0.499	2
UniProt:Q92766 RREB1			0.483	2
UniProt:Q8NDX5 PHC3	1	PHC3 [nucleoplasm] (R-HSA-389116)	0.483	2
UniProt:Q96AV8 E2F7	1	E2F7 [nucleoplasm] (R-HSA-6798305)	0.483	2
UniProt:Q6ZRI6 CO039			0.483	2

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