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STING:STING [cytoplasmic vesicle membrane]
Stable Identifier
R-HSA-3134799
Type
Complex
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
Regulation of innate immune responses to cytosolic DNA (Homo sapiens)
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Homo sapiens)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172,K48polyUb-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Homo sapiens)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING mediated induction of host immune responses (Homo sapiens)
IRF3-mediated induction of type I IFN (Homo sapiens)
IRF3 is phosphorylated by TBK1 (Homo sapiens)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING recruits TBK1 and IRF3 (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:c-di-GMP [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:cGAMP [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Homo sapiens)
STING:TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
STAT6-mediated induction of chemokines (Homo sapiens)
STING recruits TBK1 and STAT6 (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:TBK1:STAT6 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Homo sapiens)
STING:TBK1:STAT6 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1:STAT6 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
TBK1 phosphorylates STAT6 at Ser407 (Homo sapiens)
STING:p-S172-TBK1 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1:STAT6 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING binds c-di-GMP (Homo sapiens)
STING:c-di-GMP [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING binds cyclic GMP-AMP (Homo sapiens)
STING:cGAMP [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
21074459
The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA
Kawai, T
,
Abe, T
,
Akira, S
,
Matsuura, Y
,
Kumar, H
,
Zou, J
,
Tsuchida, T
,
Saitoh, T
Immunity
2010
Participants
components
x 2
K63polyUb-STING [cytoplasmic vesicle membrane]
(Homo sapiens)
Participates
as a component of
STING:p-S172,K48polyUb-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1:STAT6 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:TBK1:STAT6 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:c-di-GMP [cytoplasmic vesicle membrane] (Homo sapiens)
STING:cGAMP [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
as an input of
STING recruits TBK1 and STAT6 (Homo sapiens)
STING recruits TBK1 and IRF3 (Homo sapiens)
Inferred To
STING:STING [cytoplasmic vesicle membrane]
(Bos taurus)
STING:STING [cytoplasmic vesicle membrane]
(Danio rerio)
STING:STING [cytoplasmic vesicle membrane]
(Drosophila melanogaster)
STING:STING [cytoplasmic vesicle membrane]
(Gallus gallus)
STING:STING [cytoplasmic vesicle membrane]
(Mus musculus)
STING:STING [cytoplasmic vesicle membrane]
(Rattus norvegicus)
STING:STING [cytoplasmic vesicle membrane]
(Sus scrofa)
STING:STING [cytoplasmic vesicle membrane]
(Xenopus tropicalis)
Cross References
ComplexPortal
CPX-2127
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