STING ubiquitination by TRIM32 or TRIM56

Stable Identifier
R-HSA-3134804
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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STING ubiquitination by TRIM32 or TRIM56
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E3 ubiquitin-protein ligase TRIM32 and TRIM56 were shown to enhance type I IFN induction and cellular antiviral response by promoting K63-linked ubiquitination of STING.
Literature References
PubMed ID Title Journal Year
21074459 The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA

Kawai, T, Abe, T, Akira, S, Matsuura, Y, Kumar, H, Zou, J, Tsuchida, T, Saitoh, T

Immunity 2010
22745133 TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination

Hu, MM, Zhang, J, Shu, HB, Wang, YY

J. Biol. Chem. 2012
Participants
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Output
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as an event of
Catalyst Activity

ubiquitin-protein transferase activity of STING:TRIM32/TRIM56 [endoplasmic reticulum membrane]

Physical Entity
STING:TRIM32/TRIM56 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
STING ubiquitination by TRIM32 or TRIM56 (Bos taurus)
STING ubiquitination by TRIM32 or TRIM56 (Danio rerio)
STING ubiquitination by TRIM32 or TRIM56 (Drosophila melanogaster)
STING ubiquitination by TRIM32 or TRIM56 (Mus musculus)
STING ubiquitination by TRIM32 or TRIM56 (Rattus norvegicus)
STING ubiquitination by TRIM32 or TRIM56 (Sus scrofa)
Authored
Shamovsky, V  (2013-02-06)
Reviewed
Wu, J  (2013-05-22)
Jin, L  (2013-05-22)
D'Eustachio, P  (2013-02-11)
Created
Shamovsky, V  (2013-02-13)
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