Reactome | XRCC6 [cytosol]

XRCC6 [cytosol]

Stable Identifier

R-HSA-3134813

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ATP-dependent DNA helicase II, 70 kDa subunit, KU70, Lupus Ku autoantigen protein p70, 70 kDa subunit of Ku antigen, Thyroid-lupus autoantigen, TLAA, CTC box binding factor 75 kDa subunit, CTCBF, CTC75

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P12956 XRCC6

Gene Names

XRCC6, G22P1

Chain

initiator methionine:, chain:2-609

Reference Genes

BioGPS Gene:2547 XRCC6

COSMIC (genes):XRCC6 XRCC6

CTD Gene:2547 XRCC6

dbSNP Gene:2547 XRCC6

ENSEMBL:ENSG00000196419 XRCC6

ENSEMBL_homo_sapiens_GENE:ENSG00000196419.13 XRCC6

HGNC:4055 XRCC6

KEGG Gene (Homo sapiens):2547 XRCC6

Monarch:2547 XRCC6

NCBI Gene:2547 XRCC6

OMIM:152690 XRCC6

UCSC:P12956 XRCC6

Reference Transcript

Other Identifiers

11730714_s_at

11754932_x_at

16930678

200792_PM_at

200792_at

2547

32766_at

3300572

3946972

3946973

3946974

3946975

3946976

3946978

3946981

3946982

3946984

3946987

3946989

3946990

3946993

3946994

3946995

3946997

3946998

3946999

4025651

4025653

4025659

4025661

4025663

8073457

A_23_P120942

GE61354

GE81028

GO:0000166

GO:0000723

GO:0000725

GO:0000781

GO:0000783

GO:0000976

GO:0002218

GO:0002376

GO:0003677

GO:0003678

GO:0003684

GO:0003690

GO:0003691

GO:0003723

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005576

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005730

GO:0005829

GO:0005958

GO:0006266

GO:0006281

GO:0006303

GO:0006310

GO:0006351

GO:0006355

GO:0006974

GO:0008094

GO:0008152

GO:0010558

GO:0016020

GO:0016787

GO:0016829

GO:0016887

GO:0030154

GO:0030332

GO:0031410

GO:0032200

GO:0032508

GO:0032991

GO:0032993

GO:0034774

GO:0036211

GO:0042162

GO:0043226

GO:0043231

GO:0043564

GO:0044877

GO:0045027

GO:0045087

GO:0045621

GO:0045860

GO:0045892

GO:0045893

GO:0045944

GO:0048660

GO:0048856

GO:0051575

GO:0070418

GO:0070419

GO:0071475

GO:0071480

GO:0071481

GO:0097110

GO:0097680

GO:0098542

GO:0140097

GO:0140657

GO:1904813

HMNXSV003043756

ILMN_1743097

ILMN_2166506

J04611_at

PH_hs_0022800

TC22000339.hg

g4503840_3p_at

Participates

as a component of

Ku70:Ku80 heterodimer [cytosol] (Homo sapiens)

Other forms of this molecule

XRCC6 [secretory granule lumen]

XRCC6 [extracellular region]

XRCC6 [ficolin-1-rich granule lumen]

XRCC6 [nucleoplasm]

Cross References

RefSeq

NP_001275906.1, NP_001275905.1, NP_001460.1

OpenTargets

ENSG00000196419

GeneCards

P12956

HPA

ENSG00000196419-XRCC6

Ensembl

ENSP00000384941, ENSP00000353192, ENSG00000196419, ENST00000360079, ENST00000359308, ENST00000405878, ENST00000402580, ENSP00000352257, ENSP00000384257

PRO

P12956

Pharos - Targets

P12956

PDB

8AG4, 1JEY, 7K1K, 8EZA, 8BOT, 7K1J, 6ERG, 7LT3, 7ZYG, 7ZT6, 7SU3, 7LSY, 6ERH, 7ZWA, 8BH3, 6ERF, 7AXZ, 1JEQ, 8BHY, 7K0Y, 3RZX, 7NFE, 5Y3R, 1JJR, 7NFC, 7ZVT, 6ZHE, 7Z6O, 8ASC, 8BHV, 6ZHA, 7SGL, 8EZB, 7K1N, 8AG5, 7Z87, 7Z88

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14191 WRN	2	monoSUMO1-K356,K496,K898-WRN [nucleoplasm] (R-HSA-4568904) WRN [nucleoplasm] (R-HSA-67387)	0.897	10
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [nucleoplasm] (R-HSA-62161)	0.896	8
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.853	9
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.703	21
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.667	7
UniProt:Q13426 XRCC4	2	monoSUMO1-K210-XRCC4 [nucleoplasm] (R-HSA-4568892) XRCC4 [nucleoplasm] (R-HSA-75911)	0.656	3
UniProt:Q01831 XPC	5	XPC [nucleoplasm] (R-HSA-67441) Ub-XPC [nucleoplasm] (R-HSA-6782944) Ub,SUMO-XPC [nucleoplasm] (R-HSA-6790460) Ub,SUMO,K63polyUb-XPC [nucleoplasm] (R-HSA-6790522) monoSUMO1-K655-XPC [nucleoplasm] (R-HSA-4570458)	0.643	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	13
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.527	2
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.527	2
UniProt:Q9Y5B9 SUPT16H	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.527	2
UniProt:P16104 H2AFX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583)	0.527	2
UniProt:Q96P48 ARAP1	2	ARAP1 [cytosol] (R-HSA-3211582) p-Y231-ARAP1 [cytosol] (R-HSA-8848869)	0.508	2
UniProt:P21796 VDAC1	7	PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) Ub-VDAC1 [mitochondrial outer membrane] (R-HSA-9834989) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) K63polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-9834037) p-S65-Ub:VDAC1 [mitochondrial outer membrane] (R-HSA-9834991)	0.483	3
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.483	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.462	3
UniProt:P22415 USF1	2	USF1 [nucleoplasm] (R-HSA-9023562) pT153 USF1 [nucleoplasm] (R-HSA-9855887)	0.462	2

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