Reactome | DDX41 ubiquitination by TRIM21

DDX41 ubiquitination by TRIM21

Stable Identifier

R-HSA-3134946

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TRIM21 (Ro52/SSA1) is a member of the TRIM (Tripartite Motif) family of E3 ligases. E3 activity of TRIM21 was found to be a RING domain-dependent and required E2-conjugating enzymes UBE2D1/2/3/4 and UBE2E1/2 (Espinosa A et al. 2011).

TRIM21 can form a complex with DDX41 leading to the K48-linked ubiquitination and degradation of DDX41 (Zhang Z et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23222971	The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA Yuan, B, Weng, L, Lu, N, Zhang, Z, Liu, YJ, Bao, M	Nat. Immunol.	2012
21862588	Anti-Ro52 autoantibodies from patients with Sjögren's syndrome inhibit the Ro52 E3 ligase activity by blocking the E3/E2 interface Arrowsmith, CH, Sunnerhagen, M, Wahren-Herlenius, M, Sheng, Y, Ambrosi, A, Abelius, MS, Hennig, J, Espinosa, A, Anandapadmanaban, M, Nyberg, F	J. Biol. Chem.	2011