TRIM21 (Ro52/SSA1) is a member of the TRIM (Tripartite Motif) family of E3 ligases. E3 activity of TRIM21 was found to be a RING domain-dependent and required E2-conjugating enzymes UBE2D1/2/3/4 and UBE2E1/2 (Espinosa A et al. 2011).
TRIM21 can form a complex with DDX41 leading to the K48-linked ubiquitination and degradation of DDX41 (Zhang Z et al. 2013).
Yuan, B, Weng, L, Lu, N, Zhang, Z, Liu, YJ, Bao, M
Arrowsmith, CH, Sunnerhagen, M, Wahren-Herlenius, M, Sheng, Y, Ambrosi, A, Abelius, MS, Hennig, J, Espinosa, A, Anandapadmanaban, M, Nyberg, F
ubiquitin-protein transferase activity of TRIM21 [cytosol]
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