Reactome | DHX36 binds DNA

DHX36 binds DNA

Stable Identifier

R-HSA-3134962

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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DHX36 senses CpG-A in cytosol of human plasmacytoid dendritic cells. DEAH domain of DHX36 was found to be essential for binding CpG-A [Kim T et al 2010].

Literature References

PubMed ID	Title	Journal	Year
20696886	Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells Hanabuchi, S, Plumas, J, Pazhoor, S, Bover, L, Kim, T, Facchinetti, V, Zhang, Z, Chaperot, L, Liu, YJ, Bao, M, Qin, J	Proc. Natl. Acad. Sci. U.S.A.	2010