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p-BCL2L11 [mitochondrial outer membrane]
Stable Identifier
R-HSA-3145027
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
p-BIM
Locations in the PathwayBrowser for interactor UniProt:Q86UW9 DTX2
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of BIM and translocation to mitochondria (Homo sapiens)
Translocation of BIM to mitochondria (Homo sapiens)
p-BCL2L11 [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43521 BCL2L11
Gene Names
BCL2L11, BIM
Chain
chain:1-198
Reference Genes
BioGPS Gene:10018 BCL2L11
COSMIC (genes):BCL2L11 BCL2L11
CTD Gene:10018 BCL2L11
dbSNP Gene:10018 BCL2L11
ENSEMBL:ENSG00000153094 BCL2L11
ENSEMBL_homo_sapiens_GENE:ENSG00000153094.25 BCL2L11
HGNC:994 BCL2L11
KEGG Gene (Homo sapiens):10018 BCL2L11
Monarch:10018 BCL2L11
NCBI Gene:10018 BCL2L11
OMIM:603827 BCL2L11
UCSC:O43521 BCL2L11
Reference Transcript
RefSeq:NM_001204107.1 BCL2L11
RefSeq:NM_207002.3 BCL2L11
RefSeq:NM_138623.3 BCL2L11
RefSeq:NM_001204112.1 BCL2L11
RefSeq:NM_001204106.1 BCL2L11
RefSeq:NM_001204111.1 BCL2L11
RefSeq:NM_138627.3 BCL2L11
RefSeq:NM_138622.3 BCL2L11
RefSeq:NM_138621.4 BCL2L11
RefSeq:NM_001204110.1 BCL2L11
RefSeq:NM_138626.3 BCL2L11
RefSeq:NM_001204109.1 BCL2L11
RefSeq:NM_006538.4 BCL2L11
RefSeq:NM_138625.3 BCL2L11
RefSeq:XM_005263559.2 BCL2L11
RefSeq:NM_001204108.1 BCL2L11
RefSeq:NM_001204113.1 BCL2L11
RefSeq:NM_138624.3 BCL2L11
RefSeq:NM_207003.2 BCL2L11
Other Identifiers
10018
11718078_a_at
11718079_a_at
11718080_a_at
11735894_a_at
11735895_at
11745162_s_at
11751830_a_at
11753710_x_at
11753863_s_at
11759889_a_at
11763068_at
11763069_x_at
11763147_x_at
1553088_PM_a_at
1553088_a_at
1553096_PM_s_at
1553096_s_at
1558143_PM_a_at
1558143_a_at
208536_PM_s_at
208536_s_at
222343_PM_at
222343_at
225606_PM_at
225606_at
2500276
2500278
2500279
2500280
2500281
2500290
2500291
2500297
2500300
2500301
2500303
2500305
2500306
2500307
2500308
2500309
31611_s_at
33047_at
57243_at
60188_at
60189_g_at
65960_at
8044375
A_23_P154426
A_23_P309991
A_23_P309996
A_23_P425954
A_24_P122921
A_33_P3251932
A_33_P3398526
GE87423
GE890567
GO:0001701
GO:0001776
GO:0001782
GO:0001822
GO:0002260
GO:0002262
GO:0002376
GO:0005515
GO:0005737
GO:0005739
GO:0005741
GO:0005829
GO:0005856
GO:0005874
GO:0006915
GO:0006919
GO:0007005
GO:0007127
GO:0007155
GO:0007160
GO:0007283
GO:0008017
GO:0008092
GO:0008584
GO:0008630
GO:0009791
GO:0012501
GO:0012505
GO:0016020
GO:0019901
GO:0022414
GO:0023052
GO:0030879
GO:0031334
GO:0034976
GO:0035148
GO:0042475
GO:0042981
GO:0043029
GO:0043065
GO:0043226
GO:0043231
GO:0043525
GO:0043583
GO:0045787
GO:0046620
GO:0048066
GO:0048070
GO:0048536
GO:0048538
GO:0048856
GO:0060090
GO:0061024
GO:0065003
GO:0070227
GO:0070230
GO:0070231
GO:0070234
GO:0070242
GO:0071385
GO:0090200
GO:0097136
GO:0097140
GO:0097141
GO:0097192
GO:0140013
GO:1902110
GO:1902237
GO:1902263
GO:1903896
GO:2000271
GO:2001244
HMNXSV003021983
HMNXSV003027795
HMNXSV003040151
HMNXSV003041716
HMNXSV003046787
Hs.50760.0.A1_3p_at
Hs.84063.0.S1_3p_at
Hs2.202657.5.S1_3p_s_at
Hs2.202657.7.S1_3p_s_at
Hs2.84063.1.A1_3p_s_at
ILMN_1766541
ILMN_1774997
ILMN_2359627
PH_hs_0022197
g5729739_3p_s_at
Participates
as a member of
Bcl-XL interacting BH3-only proteins [mitochondrial outer membrane] (Homo sapiens)
Bcl-2 interacting BH-3 only proteins [mitochondrial outer membrane] (Homo sapiens)
as an output of
Translocation of BIM to mitochondria (Homo sapiens)
Other forms of this molecule
BCL2L11 [mitochondrial outer membrane]
BCL2L11(1-131)-BRAF(397-766) fusion [cytosol]
BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol]
p-S69-BCL2L11 [cytosol]
p-BCL2L11 [cytosol]
BCL2L11 [cytosol]
Inferred To
phospho-Bcl2l11 [mitochondrial outer membrane]
(Mus musculus)
phospho-Bcl2l11 [mitochondrial outer membrane]
(Rattus norvegicus)
phospho-BCL2L11 [mitochondrial outer membrane]
(Canis familiaris)
phospho-p-BCL2L11 [mitochondrial outer membrane]
(Bos taurus)
phospho-p-BCL2L11 [mitochondrial outer membrane]
(Gallus gallus)
phospho-p-BCL2L11 [mitochondrial outer membrane]
(Sus scrofa)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
NP_001191038.1
,
NP_001191040.1
,
NP_619527.1
,
NP_619528.1
,
NP_001191037.1
,
NP_619530.1
,
NP_619533.1
,
NP_001191042.1
,
NP_996886.1
,
NP_006529.1
,
NP_001191036.1
,
NP_619529.1
,
NP_996885.1
,
NP_001191041.1
,
NP_001191039.1
,
NP_001191035.1
,
NP_619532.1
,
NP_619531.1
,
XP_005263616.1
OpenTargets
ENSG00000153094
HPA
ENSG00000153094-BCL2L11
GeneCards
O43521
Ensembl
ENST00000439718
,
ENST00000405953
,
ENSP00000384641
,
ENSP00000403727
,
ENSP00000309226
,
ENSP00000401662
,
ENST00000452231
,
ENSP00000412892
,
ENST00000431217
,
ENST00000393256
,
ENSP00000376943
,
ENST00000433098
,
ENST00000415458
,
ENSP00000391292
,
ENST00000437029
,
ENST00000308659
,
ENST00000436733
,
ENSP00000393781
,
ENSP00000394640
,
ENSG00000153094
,
ENSP00000411137
PRO
O43521
Pharos - Targets
O43521
PDB
2NL9
,
5VX3
,
1F95
,
6VBX
,
2YQ6
,
2V6Q
,
5AGW
,
4QVF
,
3IO9
,
6UAB
,
6UA3
,
4ZIF
,
4B4S
,
6QFI
,
2YQ7
,
5C3G
,
5WOS
,
4YJ4
,
6TQQ
,
4ZIE
,
2K7W
,
5AGX
,
4UF3
,
3KJ0
,
4A1U
,
3KJ1
,
4ZIH
,
5VWW
,
8T5E
,
5VWV
,
4D2M
,
6RJP
,
3D7V
,
3KJ2
,
4A1W
,
5VX2
,
3FDL
,
6X8O
,
5VX0
,
3IO8
,
2VM6
,
5VWZ
,
5VWY
,
2WH6
,
5VWX
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07820 MCL1
1
MCL1 [cytosol]
(R-HSA-5661490)
0.948
19
UniProt:Q07812 BAX
3
BAX [cytosol]
(R-HSA-139916)
BAX activated [cytosol]
(R-HSA-139907)
BAX [mitochondrial outer membrane]
(R-HSA-139949)
0.943
22
UniProt:Q07817-1 BCL2L1
0.935
10
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.926
11
UniProt:Q92843 B2CL2
0.901
10
UniProt:Q9HD36 B2L10
0.832
11
UniProt:Q07817 BCL2L1
2
BCL2L1 [cytosol]
(R-HSA-50771)
BCL2L1 [mitochondrial outer membrane]
(R-HSA-114236)
0.826
11
UniProt:P97287 MCL1
0.796
7
UniProt:Q16548 BCL2A1
1
BCL2A1 [cytosol]
(R-HSA-9725307)
0.683
4
UniProt:P68451 PG045
0.621
4
UniProt:Q07440 B2LA1
0.609
2
UniProt:O43521 BCL2L11
7
BCL2L11 [mitochondrial outer membrane]
(R-HSA-2976674)
BCL2L11(1-131)-BRAF(397-766) fusion [cytosol]
(R-HSA-6802276)
BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol]
(R-HSA-6802519)
p-S69-BCL2L11 [cytosol]
(R-HSA-2976671)
p-BCL2L11 [mitochondrial outer membrane]
(R-HSA-3145027)
p-BCL2L11 [cytosol]
(R-HSA-140525)
BCL2L11 [cytosol]
(R-HSA-2976673)
0.589
2
UniProt:Q07813-1 BAX
0.558
7
UniProt:Q8N6Y0 USBP1
0.556
3
UniProt:P40855 PEX19
1
PEX19 [cytosol]
(R-HSA-3009036)
0.556
3
UniProt:Q13064 MKRN3
0.556
3
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
UniProt:P43364-2 MAGEA11
0.556
3
UniProt:Q86UW9 DTX2
1
DTX2 [cytosol]
(R-HSA-1604436)
0.556
3
UniProt:P07237 P4HB
3
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
0.556
3
UniProt:P03495 NS1
0.508
2
UniProt:Q92934 BAD
4
p-S99-BAD [cytosol]
(R-HSA-198335)
BAD [cytosol]
(R-HSA-50662)
BAD [mitochondrial outer membrane]
(R-HSA-114242)
p-S91-BAD [cytosol]
(R-HSA-217297)
0.499
2
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