Recruitment Of HIV Virion Budding Machinery

Stable Identifier
R-HSA-3159232
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
plasma membrane, cytosol, endosome membrane
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Recruitment Of HIV Virion Budding Machinery
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The human ESCRT pathway comprises more than 30 different proteins, and this complexity is expanded further by associated regulatory and ubiquitylation machinery. Functional studies have identified a minimal core set of human ESCRT proteins, machinery that is essential for HIV-1 budding. ESCRT-1 recruitment follows an unusal path. The PTAP motif in p6 mimics the ESCRT-1 recruitment motif, bypassing the need for ESCRT-0. The TSG101/ ESCRT-I and ALIX both function by recruiting downstream ESCRT-III and VPS4 complexes, which in turn mediate membrane fission and ESCRT factor recycling.

Literature References
PubMed ID Title Journal Year
23305486 Wrapping up the bad news: HIV assembly and release

Lever, AM, Meng, B

Retrovirology 2013
22762019 HIV-1 Assembly, Budding, and Maturation

Sundquist, WI, Kräusslich, HG

Cold Spring Harb Perspect Med 2012
15473846 Retrovirus budding

Sundquist, WI, Morita, E

Annu Rev Cell Dev Biol 2004
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Gillespie, ME  (2013-03-07)
Reviewed
Dube, M  (2013-05-21)
Created
Gillespie, ME  (2013-02-20)
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