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APH1A [plasma membrane]
Stable Identifier
R-HSA-3211581
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Gamma-secretase subunit APH-1A, APH1A_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
gamma-secretase cleaves EPHB2 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
APH-1 [plasma membrane] (Homo sapiens)
APH1A [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
APH-1 [plasma membrane] (Homo sapiens)
APH1A [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
APH-1 [plasma membrane] (Homo sapiens)
APH1A [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRIF signals cell death from the nucleus (Homo sapiens)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
APH-1 [plasma membrane] (Homo sapiens)
APH1A [plasma membrane] (Homo sapiens)
Regulated proteolysis of p75NTR (Homo sapiens)
gamma-secretase cleaves the p75NTR transmembrane domain (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
APH-1 [plasma membrane] (Homo sapiens)
APH1A [plasma membrane] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
Activated NOTCH1 Transmits Signal to the Nucleus (Homo sapiens)
Cleavage of CNTN1:NOTCH1 complex releases NICD1 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
APH-1 [plasma membrane] (Homo sapiens)
APH1A [plasma membrane] (Homo sapiens)
Cleavage of DNER:NOTCH1 complex releases NICD1 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
APH-1 [plasma membrane] (Homo sapiens)
APH1A [plasma membrane] (Homo sapiens)
NEXT1 is cleaved to produce NICD1 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
APH-1 [plasma membrane] (Homo sapiens)
APH1A [plasma membrane] (Homo sapiens)
Signaling by NOTCH2 (Homo sapiens)
NOTCH2 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
APH-1 [plasma membrane] (Homo sapiens)
APH1A [plasma membrane] (Homo sapiens)
NEXT2 is cleaved to produce NICD2 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
APH-1 [plasma membrane] (Homo sapiens)
APH1A [plasma membrane] (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
NEXT3 is cleaved to produce NICD3 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
APH-1 [plasma membrane] (Homo sapiens)
APH1A [plasma membrane] (Homo sapiens)
Noncanonical activation of NOTCH3 (Homo sapiens)
Gamma-secretase cleaves YBX1:NOTCH3 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
APH-1 [plasma membrane] (Homo sapiens)
APH1A [plasma membrane] (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
NOTCH4 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
Gamma-secretase cleaves NOTCH4 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
APH-1 [plasma membrane] (Homo sapiens)
APH1A [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB4 (Homo sapiens)
Nuclear signaling by ERBB4 (Homo sapiens)
Cleavage of ERBB4m80 by gamma-scretase complex (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
APH-1 [plasma membrane] (Homo sapiens)
APH1A [plasma membrane] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGFBR3 (Homo sapiens)
TGFBR3 PTM regulation (Homo sapiens)
TGFBR3(784-851) degradation (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
APH-1 [plasma membrane] (Homo sapiens)
APH1A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96BI3 APH1A
Gene Names
APH1A, PSF, CGI-78, UNQ579/PRO1141
Chain
chain:1-265
Reference Genes
BioGPS Gene:51107 APH1A
COSMIC (genes):APH1A APH1A
CTD Gene:51107 APH1A
dbSNP Gene:51107 APH1A
ENSEMBL:ENSG00000117362 APH1A
ENSEMBL_homo_sapiens_GENE:ENSG00000117362.13 APH1A
HGNC:29509 APH1A
KEGG Gene (Homo sapiens):51107 APH1A
Monarch:51107 APH1A
NCBI Gene:51107 APH1A
OMIM:607629 APH1A
UCSC:Q96BI3 APH1A
Reference Transcript
RefSeq:NM_001077628.2 APH1A
RefSeq:NM_001243771.1 APH1A
RefSeq:NM_001243772.1 APH1A
RefSeq:NM_016022.3 APH1A
Other Identifiers
11718148_a_at
11718149_x_at
11744723_a_at
11745996_x_at
11749882_x_at
11763721_x_at
11764017_x_at
1554417_PM_s_at
1554417_s_at
16692741
218389_PM_s_at
218389_s_at
237327_PM_at
237327_at
2434342
2434343
2434344
2434345
2434346
2434347
2434349
2434351
2434352
2434354
2434355
2434356
2434358
2434359
2434360
2434361
2434362
2434363
51107
56395_at
64290_at
7919729
85902_at
A_23_P12329
A_23_P930
GE58654
GE86437
GO:0000139
GO:0001656
GO:0005515
GO:0005768
GO:0005769
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0006509
GO:0007219
GO:0007220
GO:0008021
GO:0010008
GO:0010950
GO:0016020
GO:0016485
GO:0019899
GO:0023052
GO:0030674
GO:0031293
GO:0031410
GO:0032580
GO:0034205
GO:0042734
GO:0042982
GO:0042987
GO:0043085
GO:0043226
GO:0048856
GO:0051604
GO:0060090
GO:0061133
GO:0070765
GO:0097060
GO:0098772
HMNXSV003009818
Hs.192491.0.A1_3p_at
Hs2.108408.3.S1_3p_s_at
ILMN_1658472
ILMN_2398388
PH_hs_0006004
TC01003201.hg
TC01005811.hg
g7705786_3p_s_at
Participates
as a member of
APH-1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
APH1A [endosome membrane]
Inferred To
APH1A [plasma membrane]
(Bos taurus)
APH1A [plasma membrane]
(Canis familiaris)
APH1A [plasma membrane]
(Danio rerio)
APH1A [plasma membrane]
(Gallus gallus)
APH1A [plasma membrane]
(Sus scrofa)
Aph1a [plasma membrane]
(Mus musculus)
Aph1a [plasma membrane]
(Rattus norvegicus)
aph1a [plasma membrane]
(Xenopus tropicalis)
aph-1 [plasma membrane]
(Caenorhabditis elegans)
aph-1 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_057106.2
,
NP_001071096.1
,
NP_001230701.1
,
NP_001230700.1
OpenTargets
ENSG00000117362
HPA
ENSG00000117362-APH1A
GeneCards
Q96BI3
Ensembl
ENSG00000117362
,
ENSP00000358105
,
ENST00000360244
,
ENSP00000353380
,
ENST00000369109
,
ENSP00000397473
,
ENST00000414276
PRO
Q96BI3
Pharos - Targets
Q96BI3
PDB
5FN2
,
6LQG
,
7C9I
,
7Y5Z
,
8IM7
,
5FN3
,
8K8E
,
6IYC
,
7Y5T
,
5A63
,
5FN4
,
5FN5
,
7Y5X
,
6IDF
,
7D8X
,
6LR4
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y6X1 SERP1
2
SERP1 [endoplasmic reticulum membrane]
(R-HSA-381045)
SERP1 [cytosol]
(R-HSA-5250574)
0.556
3
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.556
3
UniProt:P05090 APOD
1
APOD [extracellular region]
(R-HSA-5216199)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:O43561-2 LAT
2
LAT-2 [plasma membrane]
(R-HSA-2396548)
p-5Y-LAT-2 [plasma membrane]
(R-HSA-2396597)
0.556
3
UniProt:P24593 IGFBP5
5
IGFBP5 [endoplasmic reticulum lumen]
(R-HSA-8956738)
p-IGFBP5 [endoplasmic reticulum lumen]
(R-HSA-8956988)
IGFBP5 [extracellular region]
(R-HSA-381414)
IGFBP5(21-163) [extracellular region]
(R-HSA-381415)
IGFBP5(164-272) [extracellular region]
(R-HSA-381478)
0.556
3
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