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PDCD1LG2 [plasma membrane]
Stable Identifier
R-HSA-3211774
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Programmed cell death 1 ligand 2, PD1L2_HUMAN, B7-DC
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-inhibition by PD-1 (Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
PDCD1LG2 [plasma membrane] (Homo sapiens)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Homo sapiens)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
PDCD1LG2 [plasma membrane] (Homo sapiens)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
PDCD1LG2 [plasma membrane] (Homo sapiens)
PD-1 binds B7DC and B7H1 (Homo sapiens)
B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
PDCD1LG2 [plasma membrane] (Homo sapiens)
PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
PDCD1LG2 [plasma membrane] (Homo sapiens)
Phosphorylation of PD-1 (Homo sapiens)
PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
PDCD1LG2 [plasma membrane] (Homo sapiens)
p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
PDCD1LG2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BQ51 PDCD1LG2
Gene Names
PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2
Chain
signal peptide:1-19, chain:20-273
Reference Genes
BioGPS Gene:80380 PDCD1LG2
COSMIC (genes):PDCD1LG2 PDCD1LG2
CTD Gene:80380 PDCD1LG2
dbSNP Gene:80380 PDCD1LG2
ENSEMBL:ENSG00000197646 PDCD1LG2
HGNC:18731 PDCD1LG2
KEGG:hsa:80380 PDCD1LG2
Monarch:80380 PDCD1LG2
NCBI Gene:80380 PDCD1LG2
OMIM:605723 PDCD1LG2
UCSC:Q9BQ51 PDCD1LG2
Reference Transcript
RefSeq:NM_025239.3 PDCD1LG2
Other Identifiers
11736811_a_at
11736812_at
11736813_at
11751859_a_at
17083370
220049_PM_s_at
220049_s_at
224399_PM_at
224399_at
3161114
3161115
3161120
3161126
3161135
3161136
3161137
3161140
3161142
47403_at
80380
8154245
A_14_P111176
A_23_P94412
A_33_P3213707
GE55942
GE80011
GO:0002250
GO:0002376
GO:0002682
GO:0003674
GO:0005515
GO:0005576
GO:0005886
GO:0006955
GO:0007166
GO:0009897
GO:0012505
GO:0031295
GO:0032689
GO:0032693
GO:0042102
GO:0042130
GO:0046007
GO:0071222
HMNXSV003053187
ILMN_2159272
PH_hs_0003930
TC09000038.hg
g13376849_3p_s_at
g13569409_3p_at
Participates
as a member of
B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
Inferred To
Pdcd1lg2 [plasma membrane]
(Mus musculus)
Pdcd1lg2 [plasma membrane]
(Rattus norvegicus)
PDCD1LG2 [plasma membrane]
(Bos taurus)
PDCD1LG2 [plasma membrane]
(Canis familiaris)
PDCD1LG2 [plasma membrane]
(Gallus gallus)
PDCD1LG2 [plasma membrane]
(Sus scrofa)
Cross References
ENSEMBL
ENSP00000380855
,
ENST00000397747
OpenTargets
ENSG00000197646
HPA
ENSG00000197646-PDCD1LG2
PRO
Q9BQ51
Pharos - Targets
Q9BQ51
GlyGen
Q9BQ51
PDB
8J3V
,
6UMT
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15116 PDCD1
2
PDCD1 [plasma membrane]
(R-HSA-197604)
p-Y223,Y248-PDCD1 [plasma membrane]
(R-HSA-389736)
0.74
14
UniProt:Q9NZQ7 CD274
1
CD274 [plasma membrane]
(R-HSA-3211776)
0.564
2
UniProt:P27449 ATP6V0C
7
ATP6V0C [endosome membrane]
(R-HSA-912591)
ATP6V0C [phagocytic vesicle membrane]
(R-HSA-1222603)
ATP6V0C [ficolin-1-rich granule membrane]
(R-HSA-6800908)
ATP6V0C [plasma membrane]
(R-HSA-6806254)
ATP6V0C [azurophil granule membrane]
(R-HSA-6799363)
ATP6V0C [tertiary granule membrane]
(R-HSA-6800991)
ATP6V0C [lysosomal membrane]
(R-HSA-9640194)
0.556
3
UniProt:P30825 SLC7A1
1
SLC7A1 [plasma membrane]
(R-HSA-375771)
0.556
3
UniProt:Q9H2H9 SLC38A1
1
SLC38A1 [plasma membrane]
(R-HSA-212663)
0.556
3
UniProt:O60883 GPR37L1
1
GPR37L1 [plasma membrane]
(R-HSA-5336178)
0.556
3
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