Reactome | CD274 [plasma membrane]

CD274 [plasma membrane]

Stable Identifier

R-HSA-3211776

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Programmed cell death 1 ligand 1, PD1L1_HUMAN, B7-H1

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Locations in the PathwayBrowser for interactor UniProt:Q13535 ATR

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External Reference Information

External Reference

UniProt:Q9NZQ7 CD274

Gene Names

CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1

Chain

signal peptide:1-18, chain:19-290

Reference Genes

BioGPS Gene:29126 CD274

COSMIC (genes):CD274 CD274

CTD Gene:29126 CD274

dbSNP Gene:29126 CD274

ENSEMBL:ENSG00000120217 CD274

ENSEMBL_homo_sapiens_GENE:ENSG00000120217.14 CD274

HGNC:17635 CD274

KEGG Gene (Homo sapiens):29126 CD274

Monarch:29126 CD274

NCBI Gene:29126 CD274

OMIM:605402 CD274

UCSC:Q9NZQ7 CD274

Reference Transcript

Other Identifiers

11728316_at

11745710_a_at

11753159_a_at

17083357

223834_PM_at

223834_at

227458_PM_at

227458_at

29126

3161089

3161090

3161091

3161092

3161097

3161100

3161103

3161104

3161106

3161107

56769_at

63332_at

8154233

A_23_P256487

A_23_P338479

A_33_P3381513

GE55952

GO:0002250

GO:0002376

GO:0002682

GO:0002845

GO:0003713

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005768

GO:0005856

GO:0005886

GO:0006351

GO:0006355

GO:0006955

GO:0007155

GO:0007165

GO:0007166

GO:0009897

GO:0009986

GO:0012501

GO:0012505

GO:0015629

GO:0016020

GO:0023052

GO:0030335

GO:0031295

GO:0031410

GO:0031901

GO:0032689

GO:0032693

GO:0032733

GO:0034097

GO:0035666

GO:0042102

GO:0042130

GO:0043226

GO:0045893

GO:0046007

GO:0048856

GO:0048870

GO:0055038

GO:0070062

GO:0071222

GO:0098542

GO:0140110

GO:1903556

GO:1905404

GO:2000562

GO:2001186

HMNXSV003005461

HMNXSV003047423

Hs.106149.0.A1_3p_at

ILMN_1701914

PH_hs_0025890

TC09000037.hg

g10567621_3p_at

Participates

as an output of

CD274 gene expression downstream of ALK signaling (Homo sapiens)

as a member of

B7-DC,B7-H1 [plasma membrane] (Homo sapiens)

Inferred To

Cd274 [plasma membrane] (Mus musculus)

Cd274 [plasma membrane] (Rattus norvegicus)

PDL1 [plasma membrane] (Canis familiaris)

CD274 [plasma membrane] (Gallus gallus)

CD274 [plasma membrane] (Sus scrofa)

PD-L1 [plasma membrane] (Bos taurus)

Homologues of CD274 [plasma membrane] (Gallus gallus)

PDCD1LG2 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_054862.1, NP_001254635.1

OpenTargets

ENSG00000120217

GeneCards

Q9NZQ7

HPA

ENSG00000120217-CD274

Ensembl

ENSP00000370985, ENSP00000370989, ENST00000381573, ENSG00000120217, ENST00000381577

PRO

Q9NZQ7

Pharos - Targets

Q9NZQ7

PDB

8AOM, 6NNV, 3SBW, 8AOK, 8P1O, 6YCR, 7BEA, 5GGT, 3FN3, 6PV9, 6NM8, 8K5N, 7NLD, 5GRJ, 7CZD, 5XJ4, 6RPG, 7C88, 5N2D, 5J8O, 7UXQ, 7SJQ, 7XYQ, 7TPS, 8R6Q, 8ALX, 3BIK, 7XAE, 6R3K, 5JDS, 7VUN, 7XAD, 5X8M, 6L8R, 7OUN, 7DY7, 5C3T, 6NP9, 5NIU, 7DCV, 5J89, 7UXP, 6NOS, 5O4Y, 6VQN, 4Z18, 7UXO, 4ZQK, 8JBA, 5IUS, 5O45, 6NOJ, 7YDS, 5X8L, 8OR1, 5N2F, 3BIS, 5XXY, 7UX5, 5JDR, 6NM7

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P33681 CD80	1	CD80 [plasma membrane] (R-HSA-179789)	0.876	11
UniProt:Q15116 PDCD1	2	p-Y223,Y248-PDCD1 [plasma membrane] (R-HSA-389736) PDCD1 [plasma membrane] (R-HSA-197604)	0.802	17
UniProt:Q9NX76 CMTM6	3	CMTM6 [specific granule membrane] (R-HSA-6800916) CMTM6 [plasma membrane] (R-HSA-6806275) CMTM6 [azurophil granule membrane] (R-HSA-6799141)	0.693	14
UniProt:Q9BQ51 PDCD1LG2	1	PDCD1LG2 [plasma membrane] (R-HSA-3211774)	0.564	2
UniProt:O75691 UTP20	1	UTP20 [nucleoplasm] (R-HSA-6790692)	0.527	2
UniProt:Q96JB2 COG3	2	COG3 [trans-Golgi network membrane] (R-HSA-6813865) COG3 [Golgi membrane] (R-HSA-5216030)	0.527	2
UniProt:Q96QU8 XPO6			0.527	2
UniProt:O95373 IPO7			0.527	2
UniProt:Q8N1S5 S39AB			0.527	3
UniProt:P42345 MTOR	2	MTOR [nucleoplasm] (R-HSA-5083674) MTOR [cytosol] (R-HSA-165662)	0.527	2
UniProt:P83436 COG7	2	COG7 [trans-Golgi network membrane] (R-HSA-6813873) COG7 [Golgi membrane] (R-HSA-6808726)	0.527	2
UniProt:Q9UIA9 XPO7			0.527	2
UniProt:Q8WTW3 COG1	2	COG1 [trans-Golgi network membrane] (R-HSA-6813862) COG1 [Golgi membrane] (R-HSA-6808721)	0.527	2
UniProt:Q96MW5 COG8	2	COG8 [trans-Golgi network membrane] (R-HSA-6813875) COG8 [Golgi membrane] (R-HSA-6808728)	0.527	2
UniProt:Q8TCG1 CIP2A			0.527	2
UniProt:O75146 HIP1R	3	HIP1R [cytosol] (R-HSA-8868155) HIP1R [Golgi membrane] (R-HSA-434348) HIP1R [cytoplasmic vesicle membrane] (R-HSA-434201)	0.527	2
UniProt:Q14746 COG2	2	COG2 [trans-Golgi network membrane] (R-HSA-6813863) COG2 [Golgi membrane] (R-HSA-5216080)	0.527	2
UniProt:Q9C0E2 XPO4			0.527	2
UniProt:O43156 TTI1			0.527	2
UniProt:Q8WVM7 STAG1	4	STAG1 [cytosol] (R-HSA-2484793) STAG1 [chromosome] (R-HSA-1638773) STAG1 [nucleoplasm] (R-HSA-163016) STAG1 [chromosome, centromeric region] (R-HSA-2466017)	0.527	2
UniProt:Q13315 ATM	5	Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043) ATM [nucleoplasm] (R-HSA-69484) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [peroxisomal matrix] (R-HSA-9665169) ATM [cytosol] (R-HSA-9665171)	0.527	2
UniProt:Q9UPQ8 DOLK	6	DOLK [endoplasmic reticulum membrane] (R-HSA-449274) DOLK M1I [endoplasmic reticulum membrane] (R-HSA-4755593) DOLK H408D [endoplasmic reticulum membrane] (R-HSA-4755548) DOLK C99S [endoplasmic reticulum membrane] (R-HSA-4755602) DOLK W304C [endoplasmic reticulum membrane] (R-HSA-4755557) DOLK Y441S [endoplasmic reticulum membrane] (R-HSA-4755590)	0.527	2
UniProt:Q13535 ATR	1	ATR [nucleoplasm] (R-HSA-912443)	0.527	2
UniProt:Q8IZR5 CKLF4			0.499	3

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