Reactome | CD274 [plasma membrane]

CD274 [plasma membrane]

Stable Identifier

R-HSA-3211776

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Programmed cell death 1 ligand 1, PD1L1_HUMAN, B7-H1

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Locations in the PathwayBrowser for interactor UniProt:Q8WVM7 STAG1

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External Reference Information

External Reference

UniProt:Q9NZQ7 CD274

Gene Names

CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1

Chain

signal peptide:1-18, chain:19-290

Reference Genes

COSMIC (genes):CD274 CD274

dbSNP Gene:29126 CD274

ENSEMBL:ENSG00000120217 CD274

Participates

as an output of

CD274 gene expression downstream of ALK signaling (Homo sapiens)

as a member of

B7-DC,B7-H1 [plasma membrane] (Homo sapiens)

Inferred To

Cd274 [plasma membrane] (Mus musculus)

Cd274 [plasma membrane] (Rattus norvegicus)

PDL1 [plasma membrane] (Canis familiaris)

CD274 [plasma membrane] (Gallus gallus)

CD274 [plasma membrane] (Sus scrofa)

PD-L1 [plasma membrane] (Bos taurus)

Homologues of CD274 [plasma membrane] (Gallus gallus)

PDCD1LG2 [plasma membrane] (Gallus gallus)

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P33681 CD80	1	CD80 [plasma membrane] (R-HSA-179789)	0.876	11
UniProt:Q15116 PDCD1	2	PDCD1 [plasma membrane] (R-HSA-197604) p-Y223,Y248-PDCD1 [plasma membrane] (R-HSA-389736)	0.802	17
UniProt:Q9NX76 CMTM6	3	CMTM6 [specific granule membrane] (R-HSA-6800916) CMTM6 [plasma membrane] (R-HSA-6806275) CMTM6 [azurophil granule membrane] (R-HSA-6799141)	0.693	14
UniProt:Q9BQ51 PDCD1LG2	1	PDCD1LG2 [plasma membrane] (R-HSA-3211774)	0.564	2
UniProt:O75691 UTP20	1	UTP20 [nucleoplasm] (R-HSA-6790692)	0.527	2
UniProt:Q96JB2 COG3	2	COG3 [trans-Golgi network membrane] (R-HSA-6813865) COG3 [Golgi membrane] (R-HSA-5216030)	0.527	2
UniProt:Q96QU8 XPO6			0.527	2
UniProt:O95373 IPO7			0.527	2
UniProt:Q8N1S5 S39AB			0.527	3
UniProt:P42345 MTOR	2	MTOR [cytosol] (R-HSA-165662) MTOR [nucleoplasm] (R-HSA-5083674)	0.527	2
UniProt:P83436 COG7	2	COG7 [trans-Golgi network membrane] (R-HSA-6813873) COG7 [Golgi membrane] (R-HSA-6808726)	0.527	2
UniProt:Q9UIA9 XPO7			0.527	2
UniProt:Q8WTW3 COG1	2	COG1 [trans-Golgi network membrane] (R-HSA-6813862) COG1 [Golgi membrane] (R-HSA-6808721)	0.527	2
UniProt:Q96MW5 COG8	2	COG8 [trans-Golgi network membrane] (R-HSA-6813875) COG8 [Golgi membrane] (R-HSA-6808728)	0.527	2
UniProt:Q8TCG1 CIP2A			0.527	2
UniProt:O75146 HIP1R	3	HIP1R [cytosol] (R-HSA-8868155) HIP1R [Golgi membrane] (R-HSA-434348) HIP1R [cytoplasmic vesicle membrane] (R-HSA-434201)	0.527	2
UniProt:Q14746 COG2	2	COG2 [trans-Golgi network membrane] (R-HSA-6813863) COG2 [Golgi membrane] (R-HSA-5216080)	0.527	2
UniProt:Q9UPQ8 DOLK	6	DOLK [endoplasmic reticulum membrane] (R-HSA-449274) DOLK M1I [endoplasmic reticulum membrane] (R-HSA-4755593) DOLK H408D [endoplasmic reticulum membrane] (R-HSA-4755548) DOLK C99S [endoplasmic reticulum membrane] (R-HSA-4755602) DOLK W304C [endoplasmic reticulum membrane] (R-HSA-4755557) DOLK Y441S [endoplasmic reticulum membrane] (R-HSA-4755590)	0.527	2
UniProt:Q9C0E2 XPO4			0.527	2
UniProt:O43156 TTI1			0.527	2
UniProt:Q13315 ATM	5	ATM [cytosol] (R-HSA-9665171) ATM [peroxisomal matrix] (R-HSA-9665169) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [nucleoplasm] (R-HSA-69484) Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043)	0.527	2
UniProt:Q8WVM7 STAG1	4	STAG1 [nucleoplasm] (R-HSA-163016) STAG1 [chromosome, centromeric region] (R-HSA-2466017) STAG1 [chromosome] (R-HSA-1638773) STAG1 [cytosol] (R-HSA-2484793)	0.527	2
UniProt:Q13535 ATR	1	ATR [nucleoplasm] (R-HSA-912443)	0.527	2
UniProt:Q8IZR5 CKLF4			0.499	3

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