Reactome | GADD45A [nucleoplasm]

GADD45A [nucleoplasm]

Stable Identifier

R-HSA-3215139

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

GADD45, DDIT1, Growth arrest and DNA damage-inducible protein GADD45 alpha, DNA damage-inducible transcript 1 protein

Locations in the PathwayBrowser for interactor UniProt:Q9Y6R4 M3K4

Expand all

External Reference Information

External Reference

UniProt:P24522 GADD45A

Gene Names

GADD45A, DDIT1, GADD45

Chain

chain:1-165

Reference Genes

BioGPS Gene:1647 GADD45A

COSMIC (genes):GADD45A GADD45A

CTD Gene:1647 GADD45A

dbSNP Gene:1647 GADD45A

ENSEMBL:ENSG00000116717 GADD45A

HGNC:4095 GADD45A

KEGG:hsa:1647 GADD45A

Monarch:1647 GADD45A

NCBI Gene:1647 GADD45A

OMIM:126335 GADD45A

UCSC:P24522 GADD45A

Reference Transcript

Other Identifiers

11717039_a_at

1647

16665932

1911_s_at

203725_PM_at

203725_at

2341089

2341090

2341091

2341092

2341093

2341094

2341095

2341096

2341097

2341098

2341099

2341100

2341101

7902227

A_14_P113109

A_14_P114342

A_14_P125604

A_23_P23221

GE57684

GO:0000079

GO:0000122

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0006281

GO:0006355

GO:0006915

GO:0006974

GO:0007098

GO:0012501

GO:0016525

GO:0016607

GO:0019900

GO:0033140

GO:0042770

GO:0042803

GO:0043065

GO:0043226

GO:0043537

GO:0046330

GO:0046982

GO:0051726

GO:0071260

GO:0071479

GO:0071901

GO:1900745

GO:1990841

GO:2000379

HMNXSV003043306

ILMN_1694075

ILMN_2052208

M60974_s_at

PH_hs_0004630

TC01000745.hg

g9790904_3p_at

Participates

as an output of

as a component of

as an input of

Inferred To

gadd45ab [nucleoplasm] (Danio rerio)

Gadd45 [nucleoplasm] (Drosophila melanogaster)

gadd45 [nucleoplasm] (Gallus gallus)

GADD45A [nucleoplasm] (Bos taurus)

GADD45A [nucleoplasm] (Canis familiaris)

GADD45A [nucleoplasm] (Sus scrofa)

Gadd45a [nucleoplasm] (Mus musculus)

Gadd45a [nucleoplasm] (Rattus norvegicus)

gadd45a [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001915.1, NP_001186671.1, NP_001186670.1

ENSEMBL

ENST00000370986, ENST00000370985, ENSP00000360024, ENSP00000360025

OpenTargets

ENSG00000116717

HPA

ENSG00000116717-GADD45A

PRO

P24522

Pharos - Targets

P24522

PDB

2KG4

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13561 DCTN2	1	DCTN2 [cytosol] (R-HSA-380302)	0.742	7
UniProt:Q8TAE8 GADD45GIP1	1	GADD45GIP1 [mitochondrial matrix] (R-HSA-5368253)	0.593	3
UniProt:P12004 PCNA	5	PCNA [nucleoplasm] (R-HSA-68439) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861)	0.589	3
UniProt:Q92600-3 CNOT9			0.556	5
UniProt:Q9HBI0 PARVG			0.556	3
UniProt:Q92876 KLK6			0.556	3
UniProt:Q14204 DYNC1H1	3	DYNC1H1 [cytosol] (R-HSA-380285) DYNC1H1 [azurophil granule lumen] (R-HSA-6799155) DYNC1H1 [extracellular region] (R-HSA-6806223)	0.556	3
UniProt:Q9Y6R4 M3K4			0.547	3
UniProt:P28715 ERCC5	1	ERCC5 [nucleoplasm] (R-HSA-67447)	0.544	2
UniProt:Q13569 TDG	3	TDG [nucleoplasm] (R-HSA-65812) monoSUMO1-K330-TDG [nucleoplasm] (R-HSA-4551718) polySUMO2,3-K330-TDG [nucleoplasm] (R-HSA-4551628)	0.524	3
UniProt:P52564 MAP2K6	3	MAP2K6 [cytosol] (R-HSA-167998) p-S207,T211-MAP2K6 [cytosol] (R-HSA-206255) p-S207,T211-MAP2K6 [nucleoplasm] (R-HSA-450258)	0.519	2
UniProt:Q9Y371 SHLB1			0.508	2
UniProt:P80303 NUCB2			0.508	2
UniProt:Q9GZX7 AICDA	1	AICDA [nucleoplasm] (R-HSA-452477)	0.499	5
UniProt:Q8NA61-2 CBY2			0.488	2
UniProt:Q8N448 LNX2			0.488	2

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