Reactome | PRMT1 [nucleoplasm]

PRMT1 [nucleoplasm]

Stable Identifier

R-HSA-3215140

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HRMT1L2, Protein arginine N-methyltransferase 1, Histone-arginine N-methyltransferase PRMT1, Interferon receptor 1-bound protein 4, HMT2, IR1B4

Locations in the PathwayBrowser for interactor UniProt:Q99619 SPSB2

Expand all

External Reference Information

External Reference

UniProt:Q99873 PRMT1

Gene Names

PRMT1, HMT2, HRMT1L2, IR1B4

Chain

chain:1-371

Reference Genes

BioGPS Gene:3276 PRMT1

COSMIC (genes):PRMT1 PRMT1

CTD Gene:3276 PRMT1

dbSNP Gene:3276 PRMT1

ENSEMBL:ENSG00000126457 PRMT1

ENSEMBL_homo_sapiens_GENE:ENSG00000126457.22 PRMT1

HGNC:5187 PRMT1

KEGG Gene (Homo sapiens):3276 PRMT1

Monarch:3276 PRMT1

NCBI Gene:3276 PRMT1

OMIM:602950 PRMT1

UCSC:Q99873 PRMT1

Reference Transcript

Other Identifiers

11715825_a_at

11760492_x_at

206445_PM_s_at

206445_s_at

3276

32825_at

3838813

3838814

3838815

3838817

3838820

3838821

3838822

3838824

3838825

3838827

3838828

3838831

3838832

3838834

3838838

3838839

8030437

A_21_P0000175

GE81037

GO:0001701

GO:0002376

GO:0003677

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006325

GO:0006338

GO:0006479

GO:0006807

GO:0007166

GO:0008168

GO:0008170

GO:0008276

GO:0008284

GO:0008327

GO:0008380

GO:0016274

GO:0016740

GO:0018216

GO:0019082

GO:0019899

GO:0023052

GO:0030154

GO:0030510

GO:0031175

GO:0032259

GO:0034709

GO:0035241

GO:0035242

GO:0036211

GO:0042054

GO:0042802

GO:0043170

GO:0043226

GO:0044020

GO:0044238

GO:0045648

GO:0045652

GO:0045653

GO:0045727

GO:0046329

GO:0046985

GO:0048273

GO:0048738

GO:0048856

GO:0051260

GO:0061431

GO:0065003

GO:0106080

GO:0140096

GO:1900745

GO:1904047

GO:1904263

HMNXSV003017987

HMNXSV003022154

ILMN_2347234

PH_hs_0028792

TC19002199.hg

TC19002646.hg

Y10807_s_at

g4504496_3p_s_at

Participates

as an input of

as a component of

as a member of

PRMT1,PRMT6 [nucleoplasm] (Homo sapiens)

This entity regulates

Negatively

RUNX1 binds SIN3A,(SIN3B) co-repressor (Homo sapiens)

Other forms of this molecule

PRMT1 [cytosol]

Inferred To

Art9 [nucleoplasm] (Drosophila melanogaster)

Homologues of PRMT1 [nucleoplasm] (Dictyostelium discoideum)

Homologues of PRMT1 [nucleoplasm] (Drosophila melanogaster)

Homologues of PRMT1 [nucleoplasm] (Schizosaccharomyces pombe)

Art6 [nucleoplasm] (Drosophila melanogaster)

Art8 [nucleoplasm] (Drosophila melanogaster)

Dmel\CG32152 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of PRMT1 [nucleoplasm] (Danio rerio)

Ghost homologue of PRMT1 [nucleoplasm] (Gallus gallus)

PRMT1 [nucleoplasm] (Bos taurus)

PRMT1 [nucleoplasm] (Caenorhabditis elegans)

PRMT1 [nucleoplasm] (Canis familiaris)

PRMT1 [nucleoplasm] (Dictyostelium discoideum)

PRMT1 [nucleoplasm] (Mus musculus)

PRMT1 [nucleoplasm] (Plasmodium falciparum)

PRMT1 [nucleoplasm] (Rattus norvegicus)

PRMT1 [nucleoplasm] (Saccharomyces cerevisiae)

PRMT1 [nucleoplasm] (Schizosaccharomyces pombe)

PRMT1 [nucleoplasm] (Sus scrofa)

PRMT1 [nucleoplasm] (Xenopus tropicalis)

Art2 [nucleoplasm] (Drosophila melanogaster)

Art1 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001527.3, XP_016882223.1, NP_001193971.1, XP_016882224.1, NP_938074.2

ZINC - World Drugs

ANM1_HUMAN

Guide to Pharmacology - Targets

1252

OpenTargets

ENSG00000126457

ZINC - Substances

ANM1_HUMAN

ZINC target

Q99873

ZINC - Biogenic

ANM1_HUMAN

PRO

Q99873

PDB

6NT2

ZINC - Metabolites

ANM1_HUMAN

GeneCards

Q99873

HPA

ENSG00000126457-PRMT1

Ensembl

ENST00000391851, ENST00000610806, ENST00000454376, ENSP00000484505, ENSP00000375724, ENSG00000126457, ENSP00000406162

Pharos - Targets

Q99873

ZINC - Predictions - Purchasable

ANM1_HUMAN

HMDB Protein

HMDBP11614

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43390 HNRNPR	1	HNRNPR [nucleoplasm] (R-HSA-71951)	0.742	5
UniProt:Q12906 ILF3	3	p-T188,T315-ILF3 [cytosol] (R-HSA-9836381) ILF3 [cytosol] (R-HSA-450564) ILF3 [nucleoplasm] (R-HSA-9760401)	0.727	4
UniProt:Q99873 PRMT1	2	PRMT1 [cytosol] (R-HSA-9632173) PRMT1 [nucleoplasm] (R-HSA-3215140)	0.721	4
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.657	5
UniProt:Q9NR22 ANM8			0.632	5
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.623	2
UniProt:P22736 NR4A1	2	p-S351-NR4A1 [nucleoplasm] (R-HSA-199846) NR4A1 [nucleoplasm] (R-HSA-199831)	0.623	6
UniProt:P48552 NRIP1	2	monoSUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057) NRIP1 [nucleoplasm] (R-HSA-4086031)	0.602	4
UniProt:P61978 HNRNPK	2	polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.602	3
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.564	3
UniProt:Q9Y3Y2 CHTOP	1	CHTOP [nucleoplasm] (R-HSA-8849147)	0.564	5
UniProt:Q9NR22-2 PRMT8			0.556	5
UniProt:Q15772 SPEG			0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:P49761 CLK3			0.527	2
UniProt:P19784 CSNK2A2	2	CSNK2A2 [nucleoplasm] (R-HSA-6805065) CSNK2A2 [cytosol] (R-HSA-201721)	0.527	2
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.527	2
UniProt:Q86V81 ALYREF	2	ALYREF [nucleoplasm] (R-HSA-156649) ALYREF [cytosol] (R-HSA-158482)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.525	3
UniProt:P40337 VHL	3	monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697) VHL [nucleoplasm] (R-HSA-1234127) VHL [cytosol] (R-HSA-391423)	0.508	2
UniProt:Q96BD6 SPSB1	1	SPSB1 [cytosol] (R-HSA-976024)	0.508	2
UniProt:Q5JVS0 HABP4	2	HABP4 [extracellular region] (R-HSA-448329) HABP4 [cytosol] (R-HSA-448328)	0.508	2
UniProt:P63172 DYNLT1	3	DYNLT1 [secretory granule lumen] (R-HSA-6801497) DYNLT1 [extracellular region] (R-HSA-6806509) DYNLT1 [ficolin-1-rich granule lumen] (R-HSA-6801487)	0.508	2
UniProt:Q5TAQ9 DCAF8	1	DCAF8 [nucleoplasm] (R-HSA-8955192)	0.508	2
UniProt:Q99619 SPSB2	1	SPSB2 [cytosol] (R-HSA-976048)	0.508	2
UniProt:Q01844 EWS			0.508	2
UniProt:O60506 HNRPQ			0.508	2
UniProt:Q8IZU1 FAM9A			0.508	2
UniProt:Q8IZS5 OFCC1			0.508	2
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.508	2
UniProt:P04591-PRO_0000038596 GAG			0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	2
UniProt:Q14524 SCN5A	1	SCN5A [plasma membrane] (R-HSA-443382)	0.471	2

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