Reactome | PRMT1 [nucleoplasm]

PRMT1 [nucleoplasm]

Stable Identifier

R-HSA-3215140

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HRMT1L2, Protein arginine N-methyltransferase 1, Histone-arginine N-methyltransferase PRMT1, Interferon receptor 1-bound protein 4, HMT2, IR1B4

Locations in the PathwayBrowser for interactor UniProt:Q9Y3Y2 CHTOP

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External Reference Information

External Reference

UniProt:Q99873 PRMT1

Gene Names

PRMT1, HMT2, HRMT1L2, IR1B4

Chain

chain:1-371

Reference Genes

BioGPS Gene:3276 PRMT1

COSMIC (genes):PRMT1 PRMT1

CTD Gene:3276 PRMT1

dbSNP Gene:3276 PRMT1

ENSEMBL:ENSG00000126457 PRMT1

HGNC:5187 PRMT1

KEGG:hsa:3276 PRMT1

Monarch:3276 PRMT1

NCBI Gene:3276 PRMT1

OMIM:602950 PRMT1

UCSC:Q99873 PRMT1

Reference Transcript

Participates

as an input of

as a component of

as a member of

PRMT1,PRMT6 [nucleoplasm] (Homo sapiens)

This entity regulates

Negatively

RUNX1 binds SIN3A,(SIN3B) co-repressor (Homo sapiens)

Other forms of this molecule

PRMT1 [cytosol]

Inferred To

Art9 [nucleoplasm] (Drosophila melanogaster)

Homologues of PRMT1 [nucleoplasm] (Dictyostelium discoideum)

Homologues of PRMT1 [nucleoplasm] (Drosophila melanogaster)

Homologues of PRMT1 [nucleoplasm] (Schizosaccharomyces pombe)

Art6 [nucleoplasm] (Drosophila melanogaster)

Art8 [nucleoplasm] (Drosophila melanogaster)

Dmel\CG32152 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of PRMT1 [nucleoplasm] (Danio rerio)

Ghost homologue of PRMT1 [nucleoplasm] (Gallus gallus)

PRMT1 [nucleoplasm] (Bos taurus)

PRMT1 [nucleoplasm] (Caenorhabditis elegans)

PRMT1 [nucleoplasm] (Canis familiaris)

PRMT1 [nucleoplasm] (Dictyostelium discoideum)

PRMT1 [nucleoplasm] (Mus musculus)

PRMT1 [nucleoplasm] (Plasmodium falciparum)

PRMT1 [nucleoplasm] (Rattus norvegicus)

PRMT1 [nucleoplasm] (Saccharomyces cerevisiae)

PRMT1 [nucleoplasm] (Schizosaccharomyces pombe)

PRMT1 [nucleoplasm] (Sus scrofa)

PRMT1 [nucleoplasm] (Xenopus tropicalis)

Art2 [nucleoplasm] (Drosophila melanogaster)

Art1 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

XP_016882224.1, NP_001193971.1, XP_016882223.1, NP_938074.2, NP_001527.3

Guide to Pharmacology - Targets

1252

ENSEMBL

ENST00000391851, ENST00000610806, ENSG00000126457, ENSP00000484505, ENST00000454376, ENSP00000375724, ENSP00000406162

OpenTargets

ENSG00000126457

ZINC - Substances

ANM1_HUMAN

ZINC - Biogenic

ANM1_HUMAN

ZINC target

Q99873

PRO

Q99873

GlyGen

Q99873

PDB

6NT2

ZINC - Metabolites

ANM1_HUMAN

GeneCards

PRMT1

HPA

ENSG00000126457-PRMT1

Pharos - Targets

Q99873

ZINC - Predictions - Purchasable

ANM1_HUMAN

HMDB Protein

HMDBP11614

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43390 HNRNPR	1	HNRNPR [nucleoplasm] (R-HSA-71951)	0.742	5
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.727	4
UniProt:Q99873 PRMT1	2	PRMT1 [cytosol] (R-HSA-9632173) PRMT1 [nucleoplasm] (R-HSA-3215140)	0.721	4
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.657	5
UniProt:Q9NR22 ANM8			0.632	5
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.623	2
UniProt:P22736 NR4A1	2	NR4A1 [nucleoplasm] (R-HSA-199831) p-S351-NR4A1 [nucleoplasm] (R-HSA-199846)	0.623	6
UniProt:P48552 NRIP1	2	NRIP1 [nucleoplasm] (R-HSA-4086031) monoSUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057)	0.602	4
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.602	3
UniProt:Q9Y3Y2 CHTOP	1	CHTOP [nucleoplasm] (R-HSA-8849147)	0.564	5
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.564	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q15772 SPEG			0.556	3
UniProt:Q9NR22-2 PRMT8			0.556	5
UniProt:Q86V81 ALYREF	2	ALYREF [cytosol] (R-HSA-158482) ALYREF [nucleoplasm] (R-HSA-156649)	0.527	2
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.527	2
UniProt:P19784 CSNK2A2	2	CSNK2A2 [cytosol] (R-HSA-201721) CSNK2A2 [nucleoplasm] (R-HSA-6805065)	0.527	2
UniProt:P49761 CLK3			0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.525	3
UniProt:P40337 VHL	3	VHL [cytosol] (R-HSA-391423) VHL [nucleoplasm] (R-HSA-1234127) monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697)	0.508	2
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.508	2
UniProt:Q8IZS5 OFCC1			0.508	2
UniProt:Q8IZU1 FAM9A			0.508	2
UniProt:O60506 HNRPQ			0.508	2
UniProt:Q01844 EWS			0.508	2
UniProt:Q99619 SPSB2	1	SPSB2 [cytosol] (R-HSA-976048)	0.508	2
UniProt:Q5TAQ9 DCAF8	1	DCAF8 [nucleoplasm] (R-HSA-8955192)	0.508	2
UniProt:P63172 DYNLT1	3	DYNLT1 [secretory granule lumen] (R-HSA-6801497) DYNLT1 [extracellular region] (R-HSA-6806509) DYNLT1 [ficolin-1-rich granule lumen] (R-HSA-6801487)	0.508	2
UniProt:Q5JVS0 HABP4	2	HABP4 [extracellular region] (R-HSA-448329) HABP4 [cytosol] (R-HSA-448328)	0.508	2
UniProt:Q96BD6 SPSB1	1	SPSB1 [cytosol] (R-HSA-976024)	0.508	2
UniProt:P04591-PRO_0000038596 GAG			0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	2
UniProt:Q14524 SCN5A	1	SCN5A [plasma membrane] (R-HSA-443382)	0.471	2

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