TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription

Stable Identifier
R-HSA-3215144
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm
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TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription
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Binding of TP53 (p53) to the p53 response element in the third intron of the GADD45A gene, together with chromatin modification mediated by TP53-associated proteins CARM1, PRMT1 and EP300, stimulates GADD45A transcription (An et al. 2004).

Literature References
PubMed ID Title Journal Year
15186775 Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53

Kim, J, Roeder, RG, An, W

Cell 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53:EP300:PRMT1:CARM1:GADD45A Gene [nucleoplasm] (Homo sapiens)
Active Unit
CARM1 [nucleoplasm]
p-S15,S20-TP53 Tetramer [nucleoplasm]
EP300 [nucleoplasm]
PRMT1 [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2013-03-15)
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