Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HIPK2 [nucleoplasm]
Stable Identifier
R-HSA-3215222
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Homeodomain-interacting protein kinase 2
Icon
Locations in the PathwayBrowser for interactor UniProt:Q04724 TLE1
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by MECP2 (Homo sapiens)
Regulation of MECP2 expression and activity (Homo sapiens)
HIPK2 phosphorylates MECP2 (Homo sapiens)
HIPK2 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
HIPK2 phosphorylates RUNX1 (Homo sapiens)
HIPK2 [nucleoplasm] (Homo sapiens)
HIPK2 phosphorylates RUNX1 and EP300 (Homo sapiens)
HIPK2 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
SUMOylation of HIPK2 with SUMO1 (Homo sapiens)
HIPK2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H2X6 HIPK2
Gene Names
HIPK2
Chain
chain:1-1198
Reference Genes
BioGPS Gene:28996 HIPK2
COSMIC (genes):HIPK2 HIPK2
CTD Gene:28996 HIPK2
dbSNP Gene:28996 HIPK2
ENSEMBL:ENSG00000064393 HIPK2
HGNC:14402 HIPK2
KEGG:hsa:28996 HIPK2
Monarch:28996 HIPK2
NCBI Gene:28996 HIPK2
OMIM:606868 HIPK2
UCSC:Q9H2X6 HIPK2
Reference Transcript
RefSeq:NM_022740.4 HIPK2
RefSeq:NM_001113239.2 HIPK2
Other Identifiers
11719404_a_at
11719405_a_at
11719406_a_at
11719407_a_at
11719408_a_at
11719409_a_at
11719410_s_at
11752111_a_at
11762443_at
17063461
213763_PM_at
213763_at
219028_PM_at
219028_at
224065_PM_at
224065_at
224066_PM_s_at
224066_s_at
225097_PM_at
225097_at
225115_PM_at
225115_at
225116_PM_at
225116_at
225368_PM_at
225368_at
240294_PM_at
240294_at
2404878
28996
3075777
3075779
3075780
3075781
3075782
3075783
3075784
3075785
3075786
3075787
3075788
3075789
3075794
3075795
3075796
3075798
3075799
3075800
3075802
3075804
3075805
3075810
3075812
3075814
3075816
3075817
3075818
3075849
3075868
3075869
37851_at
44036_at
55913_at
56287_at
72576_at
80844_at
8143307
85541_at
A_19_P00315668
A_19_P00321851
A_23_P169756
A_23_P169766
A_24_P500621
A_24_P681011
A_33_P3223116
A_33_P3223121
GE537256
GE54515
GE58192
GO:0000122
GO:0001654
GO:0003016
GO:0003713
GO:0003714
GO:0003824
GO:0004672
GO:0004674
GO:0004713
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0006325
GO:0006355
GO:0006468
GO:0006915
GO:0006974
GO:0007179
GO:0007224
GO:0007628
GO:0008283
GO:0008284
GO:0008344
GO:0009952
GO:0010467
GO:0010494
GO:0010842
GO:0012501
GO:0016604
GO:0016605
GO:0016740
GO:0018105
GO:0018107
GO:0030154
GO:0030182
GO:0030218
GO:0030330
GO:0030511
GO:0030514
GO:0030578
GO:0030878
GO:0032092
GO:0032991
GO:0040029
GO:0042771
GO:0043226
GO:0043524
GO:0045766
GO:0045944
GO:0046330
GO:0046332
GO:0046790
GO:0048596
GO:0048856
GO:0050877
GO:0050882
GO:0051091
GO:0051402
GO:0051726
GO:0060059
GO:0060090
GO:0060235
GO:0060395
GO:0060425
GO:0061072
GO:0061629
GO:0071456
GO:0090575
GO:0097193
GO:0106310
GO:0140096
GO:0140110
GO:1901796
GO:2000059
HMNXSV003029618
HMNXSV003048401
Hs.13417.0.S1_3p_at
Hs.155877.0.A1_3p_at
Hs.21906.0.A1_3p_at
Hs.75354.1.S1_3p_at
Hs.75354.1.S2_3p_at
Hs.75354.1.S3_3p_at
ILMN_1687440
ILMN_1719828
ILMN_1912737
PH_hs_0024580
PH_hs_0039041
TC07001915.hg
TC07003195.hg
g11493927_3p_at
g13430859_3p_at
g13430859_3p_x_at
Participates
as an input of
SUMOylation of HIPK2 with SUMO1 (Homo sapiens)
as a member of
HIPK1,2 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-HIPK2 [nucleoplasm]
monoSUMO1-K32-HIPK2 [nucleoplasm]
Inferred To
HIPK2 [nucleoplasm]
(Bos taurus)
HIPK2 [nucleoplasm]
(Caenorhabditis elegans)
HIPK2 [nucleoplasm]
(Canis familiaris)
HIPK2 [nucleoplasm]
(Dictyostelium discoideum)
HIPK2 [nucleoplasm]
(Drosophila melanogaster)
HIPK2 [nucleoplasm]
(Gallus gallus)
HIPK2 [nucleoplasm]
(Mus musculus)
HIPK2 [nucleoplasm]
(Plasmodium falciparum)
HIPK2 [nucleoplasm]
(Saccharomyces cerevisiae)
HIPK2 [nucleoplasm]
(Schizosaccharomyces pombe)
HIPK2 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001106710.1
,
NP_073577.3
ZINC - World Drugs
HIPK2_HUMAN
Guide to Pharmacology - Targets
2034
OpenTargets
ENSG00000064393
ENSEMBL
ENSP00000413724
,
ENST00000406875
,
ENSP00000385571
,
ENST00000428878
ZINC - FDA approved
HIPK2_HUMAN
ZINC - Substances
HIPK2_HUMAN
ZINC - Biogenic
HIPK2_HUMAN
ZINC target
Q9H2X6
PRO
Q9H2X6
GlyGen
Q9H2X6
PDB
6P5S
,
7NCF
ZINC - Investigational
HIPK2_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000064393-HIPK2
Pharos - Targets
Q9H2X6
ZINC - Predictions - Purchasable
HIPK2_HUMAN
HMDB Protein
HMDBP09471
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61962 DCAF7
2
Unfolded DCAF7 [cytosol]
(R-HSA-6813821)
DCAF7 [nucleoplasm]
(R-HSA-8863312)
0.729
11
UniProt:P63279 UBE2I
9
monoSUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [nuclear envelope]
(R-HSA-4655408)
SUMO2-C93-UBE2I [cytosol]
(R-HSA-4656944)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
UBE2I [nucleoplasm]
(R-HSA-912481)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
UBE2I [cytosol]
(R-HSA-4655342)
0.721
5
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.713
3
UniProt:Q01196 RUNX1
5
RUNX1 [plasma membrane]
(R-HSA-5667138)
p-S249,S273,S276-RUNX1 [nucleoplasm]
(R-HSA-8878063)
p-7Y-RUNX1 [nucleoplasm]
(R-HSA-8937712)
MeR206,MeR210-RUNX1 [nucleoplasm]
(R-HSA-8934750)
RUNX1 [nucleoplasm]
(R-HSA-8865295)
0.639
4
UniProt:Q00987 MDM2
11
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
MDM2 [cytosol]
(R-HSA-198644)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
MDM2 [plasma membrane]
(R-HSA-416843)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
0.62
5
UniProt:Q09472 EP300
5
EP300 [nucleoplasm]
(R-HSA-381325)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
0.602
4
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
SUMO1 [nucleoplasm]
(R-HSA-877304)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
0.544
2
UniProt:Q04724 TLE1
2
Ub-TLE1 [nucleoplasm]
(R-HSA-3322369)
TLE1 [nucleoplasm]
(R-HSA-212327)
0.544
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text