Reactome | CHD8 [nucleoplasm]

CHD8 [nucleoplasm]

Stable Identifier

R-HSA-3221598

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Chromodomain-helicase-DNA-binding protein 8, Helicase with SNF2 domain 1, HELSNF1, KIAA1564

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9HCK8 CHD8

Gene Names

CHD8, HELSNF1, KIAA1564

Chain

chain:1-2581

Reference Genes

BioGPS Gene:57680 CHD8

COSMIC (genes):CHD8 CHD8

CTD Gene:57680 CHD8

dbSNP Gene:57680 CHD8

ENSEMBL:ENSG00000100888 CHD8

HGNC:20153 CHD8

KEGG:hsa:57680 CHD8

Monarch:57680 CHD8

NCBI Gene:57680 CHD8

OMIM:610528 CHD8

UCSC:Q9HCK8 CHD8

Reference Transcript

Other Identifiers

11743975_a_at

11763908_at

11763909_x_at

1566340_PM_at

1566340_at

16790307

16790362

212571_PM_at

212571_at

2406504

3555935

3555936

3555937

3555938

3555939

3555940

3555941

3555942

3555943

3555944

3555946

3555950

3555951

3555952

3555953

3555954

3555955

3555956

3555957

3555958

3555959

3555960

3555961

3555962

3555963

3555964

3555965

3555966

3555967

3555968

3555969

3555970

3555971

3555972

3555973

3555974

3555975

3555976

3555977

3555979

3555980

3555981

3555983

3555984

3555985

3555986

3555987

3555988

3555989

3555991

3555992

3555993

3555994

3555995

3555996

3555997

3555998

3555999

3556000

3556001

3556002

3556003

3556004

3556005

3556006

3556007

3556008

3556009

3556014

3556015

3556019

3556020

3556366

3556384

3556385

40609_at

40980_at

57680

7977693

7977732

7977734

A_21_P0000298

A_23_P140241

A_24_P361167

A_33_P3843358

GE759364

GE88622

GO:0000122

GO:0000785

GO:0001701

GO:0001964

GO:0002039

GO:0003677

GO:0003678

GO:0003682

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0006325

GO:0006338

GO:0006355

GO:0006397

GO:0007420

GO:0008013

GO:0016055

GO:0016071

GO:0016787

GO:0016887

GO:0030178

GO:0032508

GO:0032991

GO:0035064

GO:0035176

GO:0042393

GO:0043066

GO:0043226

GO:0045892

GO:0045893

GO:0045944

GO:0045945

GO:0048565

GO:0048856

GO:0050877

GO:0060134

GO:0071339

GO:0090090

GO:0140097

GO:0140657

GO:0140658

GO:2000270

HMNXSV003009054

HMNXSV003039666

HMNXSV003055472

Hs.173421.0.S1_3p_at

Hs2.437169.1.S1_3p_at

ILMN_1806122

PH_hs_0028053

PH_hs_0040641

RNA33549|snoRNA_scaRNA_145_109

TC14000917.hg

TC14000919.hg

TC14000920.hg

Participates

as a component of

CTNNB1:CHD8 [nucleoplasm] (Homo sapiens)

as an input of

CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression (Homo sapiens)

Inferred To

kis [nucleoplasm] (Drosophila melanogaster)

chd-7 [nucleoplasm] (Caenorhabditis elegans)

CHD8 [nucleoplasm] (Bos taurus)

CHD8 [nucleoplasm] (Canis familiaris)

CHD8 [nucleoplasm] (Danio rerio)

CHD8 [nucleoplasm] (Mus musculus)

CHD8 [nucleoplasm] (Rattus norvegicus)

CHD8 [nucleoplasm] (Sus scrofa)

CHD8 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_065971.2, NP_001164100.1

OpenTargets

ENSG00000100888

ENSEMBL

ENSP00000495070, ENSP00000406288, ENSP00000494402, ENST00000430710, ENST00000645929, ENSP00000451601, ENST00000646647, ENSP00000495240, ENST00000557364, ENST00000643469

HPA

ENSG00000100888-CHD8

PRO

Q9HCK8

Pharos - Targets

Q9HCK8

Orphanet

CHD8

GlyGen

Q9HCK8

PDB

2CKA, 2DL6

HMDB Protein

HMDBP11645

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.643	3
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.623	3
UniProt:O60684 KPNA6	2	KPNA6 [nucleoplasm] (R-HSA-9734665) KPNA6 [cytosol] (R-HSA-9734672)	0.527	2
UniProt:P67870 CSNK2B	5	CSNK2B [cytosol] (R-HSA-201693) CSNK2B [nucleoplasm] (R-HSA-6805067) CSNK2B [secretory granule lumen] (R-HSA-6801319) CSNK2B [extracellular region] (R-HSA-6806508) CSNK2B [ficolin-1-rich granule lumen] (R-HSA-6801290)	0.527	2
UniProt:O95365 ZBT7A			0.508	2
UniProt:O00154 ACOT7	1	ACOT7 [cytosol] (R-HSA-5690040)	0.499	2
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.499	2
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.499	2
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.483	2
UniProt:Q13595 TRA2A			0.483	2
UniProt:P26368 U2AF2	2	U2AF2 [nucleoplasm] (R-HSA-71987) 5OHK15,276-U2AF2 [nucleoplasm] (R-HSA-9630011)	0.483	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	2
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.483	2
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.483	2
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.483	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	2
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.463	3

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