Reactome | STK11 (LKB1) phosphorylates NUAK1

STK11 (LKB1) phosphorylates NUAK1

Stable Identifier

R-HSA-3222006

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        STK11 (LKB1) phosphorylates NUAK1 (Homo sapiens)

General

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STK11 (LKB1) phosphorylates NUAK1 at threonine residue T211, resulting in NUAK1 activation (Hou et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21317932	A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation Liu, JE, Liu, ZY, Liu, W, Sun, ZY, Liu, CY, Hou, X	Oncogene	2011