NUAK1 phosphorylates TP53

Stable Identifier
R-HSA-3222020
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NUAK1 phosphorylates TP53
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NUAK1, activated by STK11 (LKB1)-mediated phosphorylation on threonine residue T211, phosphorylates TP53 (p53) on serine residues S15 and S392, contributing to TP53-mediated transcriptional activation of the CDKN1A (p21) gene (Zeng and Berger 2006, Hou et al. 2011).
Literature References
PubMed ID Title Journal Year
21317932 A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation

Hou, X, Liu, JE, Liu, W, Liu, CY, Liu, ZY, Sun, ZY

Oncogene 2011
Participants
Input
Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm]

Physical Entity
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
NUAK1 phosphorylates TP53 (Bos taurus)
NUAK1 phosphorylates TP53 (Canis familiaris)
NUAK1 phosphorylates TP53 (Mus musculus)
NUAK1 phosphorylates TP53 (Rattus norvegicus)
NUAK1 phosphorylates TP53 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2013-03-18)
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