Reactome | DAXX [nucleoplasm]

DAXX [nucleoplasm]

Stable Identifier

R-HSA-3222068

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Death domain-associated protein 6, DAP6, BING2, ETS1-associated protein 1, EAP1, Fas death domain-associated protein

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Locations in the PathwayBrowser for interactor UniProt:O43918 AIRE

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Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Diseases of Telomere Maintenance (Homo sapiens)
    - Alternative Lengthening of Telomeres (ALT) (Homo sapiens)
      - Defective Inhibition of DNA Recombination at Telomere (Homo sapiens)
        
        Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations (Homo sapiens)
        
        Defective ATRX does not bind DAXX (Homo sapiens)
        
        DAXX [nucleoplasm] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of transcription cofactors (Homo sapiens)
        
        SUMOylation of DAXX with SUMO1 (Homo sapiens)
        
        DAXX [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UER7 DAXX

Gene Names

DAXX, BING2, DAP6

Chain

chain:1-740

Reference Genes

BioGPS Gene:1616 DAXX

COSMIC (genes):DAXX DAXX

CTD Gene:1616 DAXX

dbSNP Gene:1616 DAXX

ENSEMBL:ENSG00000204209 DAXX

ENSEMBL_homo_sapiens_GENE:ENSG00000204209.13 DAXX

ENSEMBL_homo_sapiens_GENE:ENSG00000206206.11 DAXX

ENSEMBL_homo_sapiens_GENE:ENSG00000206279.10 DAXX

ENSEMBL_homo_sapiens_GENE:ENSG00000227046.8 DAXX

ENSEMBL_homo_sapiens_GENE:ENSG00000231617.8 DAXX

HGNC:2681 DAXX

KEGG Gene (Homo sapiens):1616 DAXX

Monarch:1616 DAXX

NCBI Gene:1616 DAXX

OMIM:603186 DAXX

UCSC:Q9UER7 DAXX

Reference Transcript

Other Identifiers

113523636

11719376_a_at

11738202_x_at

11747723_a_at

1616

17018240

17030053

17032737

17037538

17040248

1754_at

201763_PM_s_at

201763_s_at

2950669

2950670

2950673

2950674

2950676

2950677

2950679

2950680

2950682

2950683

2950684

41161_at

8125734

8178991

8180179

AF006041_at

A_23_P122579

GE62725

GO:0000775

GO:0001934

GO:0002039

GO:0003713

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0006325

GO:0006334

GO:0006338

GO:0006351

GO:0006355

GO:0006915

GO:0007254

GO:0008625

GO:0010468

GO:0010629

GO:0012501

GO:0016604

GO:0016605

GO:0019899

GO:0019901

GO:0023052

GO:0030295

GO:0030521

GO:0031072

GO:0031396

GO:0031625

GO:0034605

GO:0034620

GO:0036211

GO:0036480

GO:0042393

GO:0042803

GO:0042981

GO:0043226

GO:0043229

GO:0045860

GO:0045892

GO:0045893

GO:0050681

GO:0060090

GO:0061629

GO:0065003

GO:0071276

GO:0071280

GO:0072738

GO:0098772

GO:0140037

GO:0140110

GO:0140416

GO:0140693

GO:1903936

HMNXSV003049075

Hs.180224.2.S1_3p_s_at

ILMN_1708077

PH_hs_0032729

TC06001586.hg

TC06003607.hg

TC6_cox_hap2000210.hg

TC6_dbb_hap3000196.hg

TC6_mcf_hap5000185.hg

TC6_qbl_hap6000198.hg

g4503256_3p_s_at

Participates

as an input of

as a component of

as an output of

USP7 deubiquitinates MDM2 (Homo sapiens)

Other forms of this molecule

monoSUMO1-K630,K631-DAXX [nucleoplasm]

DAXX L98Vfs*13 [nucleoplasm]

DAXX R48Vfs*93 [nucleoplasm]

DAXX C74* [nucleoplasm]

DAXX S138* [nucleoplasm]

DAXX H26Tfs*118 [nucleoplasm]

DAXX E104* [nucleoplasm]

DAXX E72Nfs*72 [nucleoplasm]

DAXX C106* [nucleoplasm]

DAXX A103Sfs*40 [nucleoplasm]

DAXX K56* [nucleoplasm]

DAXX A36Qfs*108 [nucleoplasm]

Inferred To

DAXX [nucleoplasm] (Bos taurus)

DAXX [nucleoplasm] (Canis familiaris)

DAXX [nucleoplasm] (Drosophila melanogaster)

DAXX [nucleoplasm] (Plasmodium falciparum)

DAXX [nucleoplasm] (Sus scrofa)

daxx [nucleoplasm] (Xenopus tropicalis)

Daxx [nucleoplasm] (Mus musculus)

Daxx [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001241646.1, NP_001341.1, NP_001135441.1

OpenTargets

ENSG00000204209

HPA

ENSG00000204209-DAXX

GeneCards

Q9UER7

Ensembl

ENSG00000231617, ENSG00000204209, ENST00000414083, ENST00000616312, ENSP00000363668, ENST00000399344, ENSP00000480448, ENSP00000372539, ENSP00000266000, ENSP00000479172, ENST00000266000, ENSP00000483517, ENST00000455860, ENSP00000410772, ENST00000383194, ENSP00000404376, ENSP00000483394, ENST00000612868, ENST00000613912, ENSP00000478810, ENST00000622655, ENSP00000482399, ENSP00000394108, ENSP00000382281, ENST00000612888, ENST00000383062, ENSG00000227046, ENSP00000404623, ENSP00000477633, ENST00000433482, ENSP00000382014, ENST00000619421, ENSG00000206279, ENST00000436311, ENSG00000206206, ENSP00000484830, ENSP00000372681, ENST00000617660, ENST00000374542, ENST00000399060, ENSP00000396876, ENST00000445009, ENST00000620164

PRO

Q9UER7

Pharos - Targets

Q9UER7

PDB

4HGA, 5GRQ, 4H9P, 4H9O, 2KQS, 5KDM, 4H9R, 2KZS, 4H9S, 4H9N, 2KZU, 5Y18, 4H9Q, 5Y6O

Interactors (88)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.895	18
UniProt:P46100 ATRX	20	ATRX E288* [nucleoplasm] (R-HSA-9670958) ATRX K329Ifs3 [nucleoplasm] (R-HSA-9672232) ATRX Q176 [nucleoplasm] (R-HSA-9671592) ATRX C268Qfs18 [nucleoplasm] (R-HSA-9672233) ATRX Q177 [nucleoplasm] (R-HSA-9671589) ATRX K330Nfs2 [nucleoplasm] (R-HSA-9672231) ATRX G161 [nucleoplasm] (R-HSA-9671266) ATRX Q176Hfs13 [nucleoplasm] (R-HSA-9671806) ATRX R160Pfs29 [nucleoplasm] (R-HSA-9671801) ATRX K319* [nucleoplasm] (R-HSA-9671669) ATRX W222* [nucleoplasm] (R-HSA-9671670) ATRX E63* [nucleoplasm] (R-HSA-9670961) ATRX S79* [nucleoplasm] (R-HSA-9671244) ATRX H166Mfs4 [nucleoplasm] (R-HSA-9672205) ATRX Y266 [nucleoplasm] (R-HSA-9671624) ATRX L253* [nucleoplasm] (R-HSA-9671688) ATRX W263* [nucleoplasm] (R-HSA-9671685) ATRX Y187* [nucleoplasm] (R-HSA-9671622) ATRX Y204* [nucleoplasm] (R-HSA-9671619) ATRX Q292* [nucleoplasm] (R-HSA-9671581)	0.885	11
UniProt:P84243 H3-3A	18	MeK-H3F3A [nucleoplasm] (R-HSA-427369) 2xAcK-H3F3A [nucleoplasm] (R-HSA-427504) Me1K5-H3-3A [nucleoplasm] (R-HSA-9864864) MeK28-H3-3A [nucleoplasm] (R-HSA-9822942) H3R17me2a [nucleoplasm] (R-HSA-9822613) Me2K5,Me2aR2-H3F3A [nucleoplasm] (R-HSA-8936573) AcK10-H3F3A [nucleoplasm] (R-HSA-5250654) H3F3A [extracellular region] (R-HSA-977567) Me2K-10-H3F3A [nucleoplasm] (R-HSA-427324) p-T12-H3F3A [nucleoplasm] (R-HSA-5625878) p-T12,MeK-H3F3A [nucleoplasm] (R-HSA-5625858) p-T12, Me2K-10-H3F3A [nucleoplasm] (R-HSA-5625800) p-T12,Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625758) Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625747) Me3K5-H3F3A [nucleoplasm] (R-HSA-1214216) Me3K-28-H3F3A [nucleoplasm] (R-HSA-212282) H3F3A [nucleoplasm] (R-HSA-212295) Me2K5-H3F3A [nucleoplasm] (R-HSA-1214206)	0.85	8
UniProt:Q93009 USP7	2	USP7 [cytosol] (R-HSA-8853511) USP7 [nucleoplasm] (R-HSA-3215278)	0.844	16
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.84	12
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.806	7
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.795	8
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.793	11
UniProt:P29590 PML	5	polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [nucleoplasm] (R-HSA-1031706) PML [cytosol] (R-HSA-5624327)	0.791	6
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) SUMO1 [nucleoplasm] (R-HSA-877304) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.783	7
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.744	7
UniProt:Q7Z6G3-2 NECAB2			0.718	6
UniProt:Q99497 PARK7	7	monoSUMO1-K130-PARK7 [nucleoplasm] (R-HSA-4085351) PARK7 [nucleoplasm] (R-HSA-3900141) PolyUb-Misfolded PARK7 [late endosome lumen] (R-HSA-9660005) Misfolded PARK7 [cytosol] (R-HSA-9641100) Ub-Misfolded PARK7 [cytosol] (R-HSA-9641123) PolyUb-Misfolded PARK7 [cytosol] (R-HSA-9641128) PolyUb-Misfolded PARK7 [lysosomal lumen] (R-HSA-9659997)	0.714	6
UniProt:Q8ND90 PNMA1			0.696	5
UniProt:P03179 MTP			0.693	5
UniProt:P02794 FTH1	5	FTH1 [ficolin-1-rich granule lumen] (R-HSA-6801531) FTH1 [tertiary granule lumen] (R-HSA-6801508) FTH1 [cytosol] (R-HSA-434212) FTH1 [endocytic vesicle lumen] (R-HSA-2299670) FTH1 [extracellular region] (R-HSA-2187212)	0.691	5
UniProt:O43791 SPOP	1	SPOP [nucleoplasm] (R-HSA-5635035)	0.69	5
UniProt:P25445 FAS	1	FAS [plasma membrane] (R-HSA-66248)	0.674	3
UniProt:Q8IZU0 FAM9B			0.666	4
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481)	0.647	3
UniProt:Q9H2P0 ADNP			0.643	5
UniProt:P68400 CSNK2A1	2	CSNK2A1 [nucleoplasm] (R-HSA-6805057) CSNK2A1 [cytosol] (R-HSA-201713)	0.643	3
UniProt:P25446	1	Fas [plasma membrane] (R-MMU-66248)	0.635	4
UniProt:Q9NS23 RASF1			0.628	6
UniProt:P14672 SLC2A4	2	SLC2A4 [cytoplasmic vesicle membrane] (R-HSA-1449565) SLC2A4 [plasma membrane] (R-HSA-70383)	0.625	7
UniProt:P10275 AR	4	PolyUb-AR [nucleoplasm] (R-HSA-6782984) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082)	0.625	5
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.618	4
UniProt:Q9NS23-4 RASSF1			0.618	5
UniProt:Q8N726 CDKN2A	12	p14ARF [nucleoplasm] (R-HSA-1629813) p14ARF [cytosol] (R-HSA-9645669) p14ARF [mitochondrial matrix] (R-HSA-9645695) p14ARF R98L;R99S [cytosol] (R-HSA-9645730) p14ARF R82C [cytosol] (R-HSA-9645750) p14ARF R90H [cytosol] (R-HSA-9645755) p14ARF R88Q [cytosol] (R-HSA-9645754) p14ARF R87C [cytosol] (R-HSA-9645759) p14ARF R81G [cytosol] (R-HSA-9645741) p14ARF R98Q [cytosol] (R-HSA-9645757) p14ARF R99C [cytosol] (R-HSA-9645756) p14ARF V22Pfs*46 [cytosol] (R-HSA-9646285)	0.611	8
UniProt:P15991 HSPB1			0.581	3
UniProt:Q02650	1	Pax5 [nucleoplasm] (R-MMU-158583)	0.581	4
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.573	2
UniProt:O76021 RL1D1			0.564	2
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q7Z412 PEX26	2	PEX26 [cytosol] (R-HSA-9603779) PEX26 [peroxisomal membrane] (R-HSA-9033092)	0.556	3
UniProt:A0A6Q8PF08 A0A6Q8PF08			0.556	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.556	3
UniProt:Q96GN5 CDA7L			0.556	3
UniProt:Q96MT8-3 CEP63			0.556	3
UniProt:Q8WVF5 KCTD4			0.556	3
UniProt:Q6NXT2 H3C			0.556	3
UniProt:Q4G0R1 Q4G0R1			0.556	3
UniProt:Q9NPF5 DMAP1	1	DMAP1 [nucleoplasm] (R-HSA-212166)	0.556	3
UniProt:Q96IK5 GMCL1			0.556	3
UniProt:P40763 STAT3	12	Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [nucleoplasm] (R-HSA-8983188) p-STAT3 [cytosol] (R-HSA-8982823) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705-STAT3 [cytosol] (R-HSA-8983130) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.556	4
UniProt:Q495M9 USH1G	1	USH1G [cytosol] (R-HSA-9658869)	0.556	3
UniProt:Q86WH2 RASF3			0.556	3
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.556	3
UniProt:Q9P2G9-2 KLHL8			0.556	3
UniProt:Q9Y2J4 AMOTL2	1	AMOTL2 [cytosol] (R-HSA-2028606)	0.556	3
UniProt:Q8NCY6 MSD4			0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:Q4V328 GRAP1			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q9H257 CARD9	3	CARD9 [cytosol] (R-HSA-561194) CARD9 [plasma membrane] (R-HSA-5607662) p-T231-CARD9 [plasma membrane] (R-HSA-5607623)	0.556	3
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.556	5
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:Q8TD10 MIPO1			0.556	3
UniProt:Q96AQ6 PBIP1			0.556	3
UniProt:Q9HCK0 ZBT26			0.556	3
UniProt:Q8N680 ZBTB2			0.556	3
UniProt:Q9Y2D8 ADIP			0.556	3
UniProt:Q9UHC7 MKRN1	2	MKRN1 [cytosol] (R-HSA-976042) p-S109-MKRN1 [cytosol] (R-HSA-8948758)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	5
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.556	3
UniProt:Q9UJW9 SRTD3			0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q92870-2 Q928702			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	15
UniProt:Q96KE9 BTBD6	1	BTBD6 [cytosol] (R-HSA-8863208)	0.553	2
UniProt:O43918 AIRE			0.543	5
UniProt:Q9NQB0 TCF7L2	4	TCF7L2 K485fs*25 [nucleoplasm] (R-HSA-5334040) TCF7L2 R397W [nucleoplasm] (R-HSA-5339696) pT201,T212-TCF7L2 [nucleoplasm] (R-HSA-4411392) TCF7L2 [nucleoplasm] (R-HSA-201923)	0.543	5
UniProt:P03244 E1B55			0.527	4
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.527	2
UniProt:Q96HA7 TONSL			0.527	3
UniProt:Q96T58 SPEN	1	SPEN [cytosol] (R-HSA-9715142)	0.527	3
UniProt:Q9Y3E7 CHMP3	2	CHMP3 [cytosol] (R-HSA-917722) CHMP3 [endosome membrane] (R-HSA-9631191)	0.527	3
UniProt:P19784 CSNK2A2	2	CSNK2A2 [nucleoplasm] (R-HSA-6805065) CSNK2A2 [cytosol] (R-HSA-201721)	0.527	2
UniProt:Q92769 HDAC2	2	monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.524	2
UniProt:Q9P243 ZFAT			0.524	5
UniProt:Q9BZ95 NSD3	1	WHSC1L1 [nucleoplasm] (R-HSA-1183230)	0.508	2
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.508	2
UniProt:P35659 DEK	1	DEK [nucleoplasm] (R-HSA-5250643)	0.499	2
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.499	2
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.499	2
UniProt:P03243 E1B55			0.463	4

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