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SMYD2 [nucleoplasm]
Stable Identifier
R-HSA-3222233
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
N-lysine methyltransferase SMYD2, HSKM-B, Histone methyltransferase SMYD2, Lysine N-methyltransferase 3C, SET and MYND domain-containing protein 2, KMT3C
Locations in the PathwayBrowser for interactor UniProt:O60293 ZC3H1
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Methylation (Homo sapiens)
SMYD2 methylates TP53 (Homo sapiens)
SMYD2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NRG4 SMYD2
Gene Names
SMYD2, KMT3C
Chain
chain:1-433
Reference Genes
BioGPS Gene:56950 SMYD2
COSMIC (genes):SMYD2 SMYD2
CTD Gene:56950 SMYD2
dbSNP Gene:56950 SMYD2
ENSEMBL:ENSG00000143499 SMYD2
ENSEMBL_homo_sapiens_GENE:ENSG00000143499.14 SMYD2
HGNC:20982 SMYD2
KEGG Gene (Homo sapiens):56950 SMYD2
Monarch:56950 SMYD2
NCBI Gene:56950 SMYD2
OMIM:610663 SMYD2
UCSC:Q9NRG4 SMYD2
Reference Transcript
RefSeq:NM_020197.2 SMYD2
Other Identifiers
11754789_a_at
16677407
212922_PM_s_at
212922_s_at
2379762
2379763
2379764
2379778
2379779
2379780
2379781
2379787
2379791
2379792
2379793
2379794
2379798
2379800
2379804
2379805
2379806
56950
7909689
A_14_P108715
A_14_P126738
A_23_P170587
GE79557
GO:0000122
GO:0000993
GO:0002039
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0007507
GO:0008168
GO:0008285
GO:0016278
GO:0016279
GO:0016740
GO:0018026
GO:0018027
GO:0023052
GO:0032259
GO:0034968
GO:0036211
GO:0042054
GO:0043226
GO:0043516
GO:0046872
GO:0046975
GO:0048856
GO:0140096
GO:0140938
GO:0140999
GO:1901796
HMNXSV003038187
Hs.66170.1.A1_3p_a_at
PH_hs_0004043
TC01001790.hg
Participates
as a member of
WHSC1, NSD1, SMYD2, ASH1L [nucleoplasm] (Homo sapiens)
Inferred To
set-30 [nucleoplasm]
(Caenorhabditis elegans)
SET5 [nucleoplasm]
(Saccharomyces cerevisiae)
SET6 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of SMYD2 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of SMYD2 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of SMYD2 [nucleoplasm]
(Plasmodium falciparum)
Homologues of SMYD2 [nucleoplasm]
(Saccharomyces cerevisiae)
Smyd3 [nucleoplasm]
(Drosophila melanogaster)
set-10 [nucleoplasm]
(Caenorhabditis elegans)
SMYD2 [nucleoplasm]
(Bos taurus)
SMYD2 [nucleoplasm]
(Caenorhabditis elegans)
SMYD2 [nucleoplasm]
(Canis familiaris)
SMYD2 [nucleoplasm]
(Danio rerio)
SMYD2 [nucleoplasm]
(Dictyostelium discoideum)
SMYD2 [nucleoplasm]
(Mus musculus)
SMYD2 [nucleoplasm]
(Plasmodium falciparum)
SMYD2 [nucleoplasm]
(Rattus norvegicus)
SMYD2 [nucleoplasm]
(Schizosaccharomyces pombe)
SMYD2 [nucleoplasm]
(Sus scrofa)
bopA [nucleoplasm]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_064582.2
ZINC - World Drugs
SMYD2_HUMAN
Guide to Pharmacology - Targets
2714
OpenTargets
ENSG00000143499
ZINC - Substances
SMYD2_HUMAN
ZINC - Biogenic
SMYD2_HUMAN
ZINC target
Q9NRG4
PRO
Q9NRG4
PDB
5KJK
,
3S7F
,
5ARG
,
3S7J
,
5KJN
,
6CBY
,
5ARF
,
5V3H
,
6N3G
,
3RIB
,
4YND
,
6MON
,
6CBX
,
5KJM
,
4O6F
,
5WCG
,
3TG4
,
4WUY
,
3S7B
,
5KJL
,
3TG5
,
3S7D
ZINC - Metabolites
SMYD2_HUMAN
IntEnz
2.1.1.354
HPA
ENSG00000143499-SMYD2
GeneCards
Q9NRG4
Ensembl
ENST00000366957
,
ENSG00000143499
,
ENSP00000355924
Pharos - Targets
Q9NRG4
ZINC - Predictions - Purchasable
SMYD2_HUMAN
HMDB Protein
HMDBP11961
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.806
6
UniProt:Q15185 PTGES3
2
PTGES3 [nucleoplasm]
(R-HSA-5082403)
PTGES3 [cytosol]
(R-HSA-265269)
0.669
3
UniProt:Q9UPZ9 CILK1
0.657
3
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.564
2
UniProt:P20290-2 BTF3
0.556
3
UniProt:Q9Y5W9 SNX11
0.556
3
UniProt:Q96K17 BT3L4
0.556
3
UniProt:O60293 ZC3H1
0.527
2
UniProt:Q9BZS1 FOXP3
1
FOXP3 [nucleoplasm]
(R-HSA-8865539)
0.527
2
UniProt:Q9UNI1 CELA1
0.527
2
UniProt:Q9H9D4 ZN408
0.527
2
UniProt:P01160 NPPA
5
NPPA(124-151) [extracellular region]
(R-HSA-5578799)
NPPA(1-151) [extracellular region]
(R-HSA-976950)
NPPA(1-25) [extracellular region]
(R-HSA-5578791)
NPPA(56-123) [extracellular region]
(R-HSA-5578797)
NPPA(26-55) [extracellular region]
(R-HSA-5578794)
0.527
2
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