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PHF20 [nucleoplasm]
Stable Identifier
R-HSA-3222239
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
PHD finger protein 20, Glioma-expressed antigen 2, Hepatocellular carcinoma-associated antigen 58, Novel zinc finger protein, Transcription factor TZP, C20orf104, GLEA2, HCA58, NZF, TZP
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G1/S DNA Damage Checkpoints (Homo sapiens)
p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
p53-Dependent G1 DNA Damage Response (Homo sapiens)
Stabilization of p53 (Homo sapiens)
MDM2 binds TP53 (Homo sapiens)
PHF20 [nucleoplasm] (Homo sapiens)
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HATs acetylate histones (Homo sapiens)
NSL acetylates histone H4 (Homo sapiens)
NSL (PHF20) [nucleoplasm] (Homo sapiens)
PHF20 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
Formation of WDR5-containing histone-modifying complexes (Homo sapiens)
Formation of the NSL complex (Homo sapiens)
NSL [nucleoplasm] (Homo sapiens)
NSL (PHF20) [nucleoplasm] (Homo sapiens)
PHF20 [nucleoplasm] (Homo sapiens)
PHF20, PHF20L1 [nucleoplasm] (Homo sapiens)
PHF20 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Association with Co-factors (Homo sapiens)
AKT phosphorylates PHF20 (Homo sapiens)
PHF20 [nucleoplasm] (Homo sapiens)
PHF20 binds TP53 dimethylated on K370 and K382 (Homo sapiens)
PHF20 [nucleoplasm] (Homo sapiens)
PHF20:Me2-K370,K382-TP53 Tetramer [nucleoplasm] (Homo sapiens)
PHF20 [nucleoplasm] (Homo sapiens)
Regulation of TP53 Expression and Degradation (Homo sapiens)
Regulation of TP53 Degradation (Homo sapiens)
MDM2 binds TP53 (Homo sapiens)
PHF20 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BVI0 PHF20
Gene Names
PHF20, C20orf104, GLEA2, HCA58, NZF, TZP
Chain
chain:1-1012
Reference Genes
BioGPS Gene:51230 PHF20
COSMIC (genes):PHF20 PHF20
CTD Gene:51230 PHF20
dbSNP Gene:51230 PHF20
ENSEMBL:ENSG00000025293 PHF20
HGNC:16098 PHF20
KEGG:hsa:51230 PHF20
Monarch:51230 PHF20
NCBI Gene:51230 PHF20
OMIM:610335 PHF20
UCSC:Q9BVI0 PHF20
Reference Transcript
RefSeq:XM_017027866.1 PHF20
RefSeq:NM_016436.4 PHF20
RefSeq:XM_017027865.1 PHF20
RefSeq:XM_017027867.1 PHF20
RefSeq:XM_017027864.1 PHF20
Other Identifiers
11736332_a_at
11736333_at
11755404_a_at
1569906_PM_s_at
1569906_s_at
16913206
206567_PM_s_at
206567_s_at
209422_PM_at
209422_at
209423_PM_s_at
209423_s_at
235389_PM_at
235389_at
32884_at
35050_at
3883550
3883551
3883553
3883555
3883556
3883557
3883558
3883569
3883571
3883573
3883574
3883575
3883576
3883578
3883579
3883580
3883581
3883583
3883584
3883585
3883586
3883600
3883601
3883605
3883606
3883607
3883608
3883611
3883618
3883621
3883622
3883627
3883628
3883629
3883630
3883631
3883636
48278_at
50384_s_at
51230
51684_at
59343_at
59345_at
59348_g_at
77574_at
8062213
A_14_P103587
A_14_P121409
A_23_P210969
A_23_P428835
A_24_P181944
A_24_P297098
GE62860
GE811791
GO:0000123
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0006325
GO:0006355
GO:0006357
GO:0031965
GO:0043226
GO:0044545
GO:0045893
GO:0046872
GO:0071339
HMNXSV003006218
Hs.112594.0.S3_3p_at
Hs.87113.0.A1_3p_at
Hs2.434248.1.S1_3p_s_at
ILMN_1813657
L09749_at
PH_hs_0015507
TC20000260.hg
g13195150_3p_a_at
g7705990_3p_s_at
Participates
as a member of
PHF20, PHF20L1 [nucleoplasm] (Homo sapiens)
as a component of
NSL (PHF20) [nucleoplasm] (Homo sapiens)
PHF20:Me2-K370,K382-TP53 Tetramer [nucleoplasm] (Homo sapiens)
as an input of
AKT phosphorylates PHF20 (Homo sapiens)
PHF20 binds TP53 dimethylated on K370 and K382 (Homo sapiens)
This entity regulates
Negatively
MDM2 binds TP53
(Homo sapiens)
Other forms of this molecule
p-S291-PHF20 [nucleoplasm]
Inferred To
PHF20 [nucleoplasm]
(Bos taurus)
PHF20 [nucleoplasm]
(Canis familiaris)
PHF20 [nucleoplasm]
(Gallus gallus)
PHF20 [nucleoplasm]
(Sus scrofa)
MBD-R2 [nucleoplasm]
(Drosophila melanogaster)
Phf20 [nucleoplasm]
(Mus musculus)
Phf20 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
XP_016883354.1
,
XP_016883355.1
,
XP_016883353.1
,
NP_057520.2
,
XP_016883356.1
ENSEMBL
ENST00000374012
,
ENSP00000363124
OpenTargets
ENSG00000025293
HPA
ENSG00000025293-PHF20
PRO
Q9BVI0
Pharos - Targets
Q9BVI0
GlyGen
Q9BVI0
PDB
2LDM
,
3P8D
,
3Q1J
,
5TBN
,
3QII
,
3SD4
,
5TAB
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P68431 HIST1H3G
20
2xAcK-HIST1H3A [nucleoplasm]
(R-HSA-427507)
Me1K5-H3C1 [nucleoplasm]
(R-HSA-9677683)
Ack-Me3K5-HIST1H3A [nucleoplasm]
(R-HSA-4551293)
AcK-Me3K10-HIST1H3A [nucleoplasm]
(R-HSA-4551291)
AcK-Me3K28-HIST1H3A [nucleoplasm]
(R-HSA-4551292)
Me2aR27-HIST1H3A [nucleoplasm]
(R-HSA-5229052)
Me2aR18-HIST1H3A [nucleoplasm]
(R-HSA-5229062)
Me2sR9-HIST1H3A [nucleoplasm]
(R-HSA-5211328)
Me2sR3-HIST1H3A [nucleoplasm]
(R-HSA-5218935)
AcK9,14-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8870893)
AcK14,18,79-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871271)
AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871306)
AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871294)
AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8865596)
AcK14,18-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871295)
AcK14,18,79-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871288)
AcK14,18-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871299)
AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871286)
Me2K28-HIST1H3A [nucleoplasm]
(R-HSA-4754193)
MeK37-HIST1H3A [nucleoplasm]
(R-HSA-4722135)
0.655
6
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.643
3
UniProt:P62805 H4C1
17
HIST1H4 [nucleoplasm]
(R-HSA-181902)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
HIST1H4A [extracellular region]
(R-HSA-977569)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
0.618
3
UniProt:Q9H9L4 KANSL2
1
KANSL2 [nucleoplasm]
(R-HSA-3321796)
0.527
2
UniProt:Q7Z3B3 KANSL1
1
KANSL1 [nucleoplasm]
(R-HSA-3321875)
0.527
3
UniProt:Q15678 PTPN14
1
PTPN14 [nucleoplasm]
(R-HSA-9008917)
0.527
2
UniProt:Q9P2N6 KANSL3
1
KANSL3 [nucleoplasm]
(R-HSA-3321882)
0.499
2
UniProt:Q5NCY0 Kdm6b
2
Kdm6b [nucleoplasm]
(R-MMU-9822927)
KDM6B [nucleoplasm]
(R-MMU-1629833)
0.488
2
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