Reactome | KDM6B demethylates H3K27me3 on p16INK4A promoter

KDM6B demethylates H3K27me3 on p16INK4A promoter

Stable Identifier

R-HSA-3222593

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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KDM6B demethylates H3K27me3 on p16INK4A promoter

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Histone demethylase KDM6B (JMJD3) demethylates H3K27Me3 marks i.e. removes methyl groups from lysine 28 of histone HIST1H3A on CDKN2A locus, thereby activating CDKN2A transcription. In human cells, H3K27Me3 marks are predominantly found around the first exon of p16INK4A, and KDM6B therefore activates p16INK4A transcription but not p14ARF transcription. In mouse cells, H3K27Me3 marks are found throughout the Cdkn2a locus and Kdm6b demethylase activity induces transcription of both p16Ink4a and p19Arf. KDM6B action promotes both the oncogene-induced and oxidative stress-induced senescence (Agger et al. 2009, Barradas et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19451217	The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence Helin, K, Rudkjaer, L, Christensen, J, Andersen, G, Agger, K, Williams, K, Cloos, PA	Genes Dev.	2009
19451218	Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS Peters, G, Banck, M, Zhou, MM, Gil, J, Walsh, MJ, Li, S, Maertens, G, Acosta, JC, Barradas, M, Anderton, E, Rodriguez-Niedenführ, M, Banito, A	Genes Dev.	2009