While binding of the PRC1.4 complex to the H3K27Me3 mark on the promoter of p16INK4A inhibits p16INK4A transcription (Dietrich et al. 2007, Agherbi et al. 2009), KDM6B-mediated demethylation of lysine 28 of histone HIST1H3A (the removal of H3K27Me3 mark) stimulates p16INK4A transcription (Agger et al. 2009, Barradas et al. 2009).
Helin, K, Rudkjaer, L, Christensen, J, Andersen, G, Agger, K, Williams, K, Cloos, PA
Helin, K, Schjerling, CK, Dietrich, N, Koseki, H, Bracken, AP, Hansen, KH, Rappsilber, J, Trinh, E
Agherbi, H, Serrano, M, Chasson, L, Verthuy, C, Djabali, M, Gaussmann-Wenger, A
Peters, G, Banck, M, Zhou, MM, Gil, J, Walsh, MJ, Li, S, Maertens, G, Acosta, JC, Barradas, M, Anderton, E, Rodriguez-Niedenführ, M, Banito, A
© 2022 Reactome
