p-MAPKAPK3 phosphorylates BMI1

Stable Identifier
R-HSA-3229102
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p-MAPKAPK3 phosphorylates BMI1
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In response to stress-activated p38 signaling, MAPKAPK3 phosphorylates BMI1, leading to the dissociation of the PRC1.4 complex from chromatin and transcription of p14-ARF (Voncken et al. 2005).

Literature References
PubMed ID Title Journal Year
15563468 MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1

Ludwig, S, Voncken, JW, Neufeld, B, Kubben, N, Niessen, H, Dahlmans, V, Rennefahrt, U, Holzer, B, Rapp, UR

J. Biol. Chem. 2005
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of phospho-MAPK p38:p-MAPKAPK3 [nucleoplasm]

Physical Entity
phospho-MAPK p38:p-MAPKAPK3 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
p-MAPKAPK3 phosphorylates BMI1 (Bos taurus)
p-MAPKAPK3 phosphorylates BMI1 (Canis familiaris)
p-MAPKAPK3 phosphorylates BMI1 (Danio rerio)
p-MAPKAPK3 phosphorylates BMI1 (Gallus gallus)
p-MAPKAPK3 phosphorylates BMI1 (Rattus norvegicus)
p-MAPKAPK3 phosphorylates BMI1 (Sus scrofa)
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-03-26)
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