MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)

Stable Identifier
R-HSA-3229152
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)
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MAP3K5 (ASK1) phosphorylates and activates MAP2K4 (SEK1) (Ichijo et al. 1997). MAP3K5-mediated phosphorylation of MAP2K4 may be facilitated by MAPK8IP3 (JSAP1) (Matsuura et al. 2002).
Literature References
PubMed ID Title Journal Year
12189133 Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade

Amagasa, T, Ito, M, Ichijo, H, Nishitoh, H, Matsuzawa, A, Yoshioka, K, Takeda, K, Matsuura, H

J. Biol. Chem. 2002
8974401 Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

Nishida, E, Irie, K, Ichijo, H, Matsumoto, K, Saitoh, M, ten Dijke, P, Gotoh, Y, Moriguchi, T, Miyazono, K, Takagi, M

Science 1997
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Catalyst Activity

protein serine/threonine kinase activity of MAP3K5 [cytosol]

Physical Entity
MAP3K5 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
MAP3K5 (ASK1) phosphorylates Map2k4(Sek1) (Homo sapiens)
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-03-26)
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