MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)

Stable Identifier
R-HSA-3229152
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

MAP3K5 (ASK1) phosphorylates and activates MAP2K4 (SEK1) (Ichijo et al. 1997). MAP3K5-mediated phosphorylation of MAP2K4 may be facilitated by MAPK8IP3 (JSAP1) (Matsuura et al. 2002).

Literature References
PubMed ID Title Journal Year
12189133 Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade

Amagasa, T, Ito, M, Ichijo, H, Nishitoh, H, Matsuzawa, A, Yoshioka, K, Takeda, K, Matsuura, H

J. Biol. Chem. 2002
8974401 Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

Nishida, E, Irie, K, Ichijo, H, Matsumoto, K, Saitoh, M, ten Dijke, P, Gotoh, Y, Moriguchi, T, Miyazono, K, Takagi, M

Science 1997
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of MAP3K5 [cytosol]

Physical Entity
MAP3K5 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
MAP3K5 (ASK1) phosphorylates Map2k4(Sek1) (Homo sapiens)
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-03-26)
Cite Us!