Reactome | CPB1 [extracellular region]

CPB1 [extracellular region]

Stable Identifier

R-HSA-3229247

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Carboxypeptidase B ecNumber3.4.17.2/ecNumber, CBPB1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P15086 CPB1

Gene Names

CPB1, CPB, PCPB

Chain

signal peptide:1-15, propeptide:16-110, chain:111-417

Reference Genes

BioGPS Gene:1360 CPB1

COSMIC (genes):CPB1 CPB1

CTD Gene:1360 CPB1

dbSNP Gene:1360 CPB1

ENSEMBL:ENSG00000153002 CPB1

HGNC:2299 CPB1

Monarch:1360 CPB1

NCBI Gene:1360 CPB1

OMIM:114852 CPB1

UCSC:P15086 CPB1

Reference Transcript

RefSeq:NM_001871.2 CPB1

Other Identifiers

11715443_a_at

11715444_at

1360

16946721

205509_PM_at

205509_at

2647066

2647074

2647075

2647076

2647077

2647080

2647084

2647085

2647086

2647087

2647090

2647091

2647092

2647099

2647100

2647101

2647102

2647103

2647104

2647106

2647107

2647108

41210_at

8083246

A_14_P119852

A_14_P132958

A_23_P6615

GE81081

GO:0003824

GO:0004180

GO:0004181

GO:0005515

GO:0005576

GO:0005615

GO:0006508

GO:0008237

GO:0008270

GO:0016787

GO:0031410

GO:0043226

GO:0046872

GO:0140096

HMNXSV003047827

ILMN_1685174

M81057_at

PH_hs_0025564

PH_hs_0033402

TC03000799.hg

g4503002_3p_at

Participates

as a candidate of

Carboxypeptidase B [extracellular region] (Homo sapiens)

Other forms of this molecule

pro-CPB1 [zymogen granule]

Inferred To

Dmel\CG3097 [extracellular region] (Drosophila melanogaster)

CPB1 [extracellular region] (Bos taurus)

CPB1 [extracellular region] (Caenorhabditis elegans)

CPB1 [extracellular region] (Drosophila melanogaster)

CPB1 [extracellular region] (Rattus norvegicus)

Dmel\CG2915 [extracellular region] (Drosophila melanogaster)

Dmel\CG8539 [extracellular region] (Drosophila melanogaster)

Dmel\CG8563 [extracellular region] (Drosophila melanogaster)

Dmel\CG8564 [extracellular region] (Drosophila melanogaster)

carboxypeptidase b1 [extracellular region] (Drosophila melanogaster)

Dmel\CG8562 [extracellular region] (Drosophila melanogaster)

Homologues of CPB1 [extracellular region] (Caenorhabditis elegans)

Homologues of CPB1 [extracellular region] (Drosophila melanogaster)

Cg8945 [extracellular region] (Drosophila melanogaster)

anon-WO0140519.63 [extracellular region] (Drosophila melanogaster)

CG18415 [extracellular region] (Drosophila melanogaster)

Cpb1 [extracellular region] (Mus musculus)

Dmel\CG4408 [extracellular region] (Drosophila melanogaster)

Dmel\CG14820 [extracellular region] (Drosophila melanogaster)

cpb1 [extracellular region] (Danio rerio)

CG15768 [extracellular region] (Drosophila melanogaster)

Dmel\CG18585 [extracellular region] (Drosophila melanogaster)

Dmel\CG8560 [extracellular region] (Drosophila melanogaster)

Dmel\CG3108 [extracellular region] (Drosophila melanogaster)

Dmel\CG7025 [extracellular region] (Drosophila melanogaster)

Dmel\CG4017 [extracellular region] (Drosophila melanogaster)

Cross References

Guide to Pharmacology - Targets

1593

ENSEMBL

ENSP00000417222, ENSP00000282957, ENST00000491148

OpenTargets

ENSG00000153002

ZINC - Substances

CBPB1_HUMAN

ZINC - Biogenic

CBPB1_HUMAN

ZINC target

P15086

PRO

P15086

PDB

1KWM, 1ZLI

ZINC - Investigational

CBPB1_HUMAN

ZINC - Metabolites

CBPB1_HUMAN

IntEnz

3.4.17.2

HPA

ENSG00000153002-CPB1

Pharos - Targets

P15086

ZINC - Predictions - Purchasable

CBPB1_HUMAN

HMDB Protein

HMDBP10015

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3

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