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What is Reactome ?
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Docs
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Cytomics
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Aldo-keto reductase family [cytosol]
Stable Identifier
R-HSA-3229260
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol (Homo sapiens)
Aldo-keto reductase family [cytosol] (Homo sapiens)
General
This CandidateSet contains sequences identified by William Pearson's analysis of Reactome catalyst entities. Catalyst entity sequences were used to identify analagous sequences that shared overall homology and active site homology. Sequences in this Candidate set were identified in an April 24, 2012 analysis. Further candidates were identified by Ralf Stephan in a July 15, 2023 analysis.
Literature References
PubMed ID
Title
Journal
Year
Catalyst Sequence Similarity Project
Pearson, W
Participants
members
AKR1C4 [cytosol]
(Homo sapiens)
candidates
AKR1C1 [cytosol]
(Homo sapiens)
AKR1C3 [cytosol]
(Homo sapiens)
AKR1C2 [cytosol]
(Homo sapiens)
Inferred To
Homologues of AKR1C4 [cytosol]
(Caenorhabditis elegans)
Homologues of AKR1C4 [cytosol]
(Dictyostelium discoideum)
Homologues of AKR1C4 [cytosol]
(Drosophila melanogaster)
Homologues of AKR1C4 [cytosol]
(Saccharomyces cerevisiae)
Homologues of AKR1C4 [cytosol]
(Schizosaccharomyces pombe)
Homologues of AKR1C4 [cytosol]
(Xenopus tropicalis)
Aldo-keto reductase family [cytosol]
(Bos taurus)
Aldo-keto reductase family [cytosol]
(Mus musculus)
Aldo-keto reductase family [cytosol]
(Rattus norvegicus)
Aldo-keto reductase family [cytosol]
(Sus scrofa)
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