Reactome | monoSUMO1-K10-TFAP2C [nucleoplasm]

monoSUMO1-K10-TFAP2C [nucleoplasm]

Stable Identifier

R-HSA-3234071

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SUMO1 N-glycyl-lys10 TFAP2C, Transcription factor AP-2 gamma, AP2C_HUMAN, TFAP2C

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors (Homo sapiens)
      - Negative regulation of activity of TFAP2 (AP-2) family transcription factors (Homo sapiens)
        
        SUMOylation of TFAP2C with SUMO1 (Homo sapiens)
        
        SUMO1:TFAP2C homodimer [nucleoplasm] (Homo sapiens)
        
        monoSUMO1-K10-TFAP2C [nucleoplasm] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of transcription factors (Homo sapiens)
        
        SUMOylation of TFAP2C with SUMO1 (Homo sapiens)
        
        SUMO1:TFAP2C homodimer [nucleoplasm] (Homo sapiens)
        
        monoSUMO1-K10-TFAP2C [nucleoplasm] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
12072434	Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo Eloranta, JJ, Hurst, HC	J. Biol. Chem.	2002

External Reference Information

External Reference

UniProt:Q92754 TFAP2C

Gene Names

TFAP2C

Chain

chain:1-450

Reference Genes

BioGPS Gene:7022 TFAP2C

COSMIC (genes):TFAP2C TFAP2C

CTD Gene:7022 TFAP2C

dbSNP Gene:7022 TFAP2C

ENSEMBL:ENSG00000087510 TFAP2C

HGNC:11744 TFAP2C

KEGG:hsa:7022 TFAP2C

Monarch:7022 TFAP2C

NCBI Gene:7022 TFAP2C

OMIM:601602 TFAP2C

UCSC:Q92754 TFAP2C

Reference Transcript

RefSeq:NM_003222.3 TFAP2C

Other Identifiers

11726192_at

11749776_a_at

16915091

205286_PM_at

205286_at

205287_PM_s_at

205287_s_at

3890335

3890336

3890337

3890341

3890342

3890343

3890344

3890345

3890348

3890349

3890350

3890351

3890352

40303_at

7022

8063536

A_14_P138033

A_23_P120472

GE59504

GE79079

GO:0000122

GO:0000785

GO:0000977

GO:0000978

GO:0000981

GO:0001227

GO:0001228

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005739

GO:0005829

GO:0006325

GO:0006355

GO:0006357

GO:0007267

GO:0008584

GO:0022414

GO:0023052

GO:0042127

GO:0043226

GO:0045814

GO:0045944

GO:0048856

GO:0140110

GO:1990837

HMNXSV003040291

ILMN_1683891

ILMN_2096784

PH_hs_0020945

TC20000436.hg

U85658_at

g2058552_3p_at

g4507444_3p_a_at

Participates

as a component of

SUMO1:TFAP2C homodimer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

TFAP2C [cytosol]

TFAP2C [nucleoplasm]

Inferred To

aptf-2 [nucleoplasm] (Caenorhabditis elegans)

Homologues of monoSUMO1-K10-TFAP2C [nucleoplasm] (Caenorhabditis elegans)

TFAP2C [nucleoplasm] (Bos taurus)

TFAP2C [nucleoplasm] (Gallus gallus)

TFAP2C [nucleoplasm] (Sus scrofa)

Tfap2c [nucleoplasm] (Mus musculus)

Tfap2c [nucleoplasm] (Rattus norvegicus)

aptf-1 [nucleoplasm] (Caenorhabditis elegans)

tfap2c [nucleoplasm] (Danio rerio)

tfap2c [nucleoplasm] (Xenopus tropicalis)

aptf-4 [nucleoplasm] (Caenorhabditis elegans)

aptf-3 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 10

Coordinate

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

ENSEMBL

ENST00000201031, ENSP00000201031

OpenTargets

ENSG00000087510

HPA

ENSG00000087510-TFAP2C

PRO

Q92754

Pharos - Targets

Q92754

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342)	0.646	5
IntAct:EBI-9679441 HUMAN			0.576	3
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.532	4
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:Q99967 CITED2	1	CITED2 [nucleoplasm] (R-HSA-6804489)	0.508	2