SUMOylation of TFAP2C with SUMO1

Stable Identifier
R-HSA-3234094
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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UBE2I (UBC9) interacts with the C-terminal region of TFAP2C (Eloranta and Hurst 2002). SUMOylation of TFAP2C occurs at lysine-10 and causes a reduction in its transcriptional activation activity. A dominant negative mutant of UBC9 led to increased activity of TFAP2C therefore UBC9 is assumed to catalyze the ligation of SUMO1 to TFAP2C.
Literature References
PubMed ID Title Journal Year
12072434 Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo

Eloranta, JJ, Hurst, HC

J. Biol. Chem. 2002
Participants
Participates
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]

Orthologous Events
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Reviewed
Created
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