Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5

Stable Identifier
Reaction [transition]
Homo sapiens
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MAPKAPK5 (PRAK) forms a complex with MAPK14 (p38 alpha) or MAPK11 (p38 beta) irrespective of the phosphorylation status and kinase activity of MAPKAPK5, MAPK14 and MAPK11 (New et al. 2003). Phosphorylation of p38 alpha and p38 beta by MKK3 or MKK6 (Raingeaud et al. 1996), however, is required for the subsequent activation of MAPKAPK5 by p38 MAPK (New et al. 1998, Sun et al. 2007).
Literature References
PubMed ID Title Journal Year
12808055 Regulation of PRAK subcellular location by p38 MAP kinases

Jiang, Y, Han, J, New, L

Mol. Biol. Cell 2003
17254968 PRAK is essential for ras-induced senescence and tumor suppression

Li, Y, Yamout, M, Sun, P, Frangou, CG, Yates, JR, Liao, R, Wright, PE, Yoshizuka, N, Deng, Q, Dong, MQ, Xie, C, Chen, J, Han, J, New, L, Moser, BA

Cell 2007
8622669 MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

Davis, RJ, Whitmarsh, AJ, Derijard, B, Raingeaud, J, Barrett, T

Mol Cell Biol 1996
9628874 PRAK, a novel protein kinase regulated by the p38 MAP kinase

Kato, Y, Zhu, W, Han, J, Liu, K, Flood, LJ, Zhao, M, Jiang, Y, Parry, GC, New, L

EMBO J. 1998
Catalyst Activity

MAP kinase kinase activity of p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm]

Orthologous Events
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