Activated MAPKAPK5 (PRAK) phosphorylates TP53 (p53) on serine residue S37, thereby activating it. MAPKAPK5-mediated phosphorylation of TP53 promotes growth arrest and senescence induced by oncogenic RAS, but is not needed for TP53-dependent growth arrest in response to DNA damage (Sun et al. 2007).
Li, Y, Yamout, M, Sun, P, Frangou, CG, Yates, JR, Liao, R, Wright, PE, Yoshizuka, N, Deng, Q, Dong, MQ, Xie, C, Chen, J, Han, J, New, L, Moser, BA
protein serine/threonine kinase activity of phospho-p38 MAPK:p-T-182-MAPKAPK5 [nucleoplasm]
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