Reactome | MAPKAPK5 phosphorylates TP53

MAPKAPK5 phosphorylates TP53

Stable Identifier

R-HSA-3239014

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        MAPKAPK5 phosphorylates TP53 (Homo sapiens)

General

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Activated MAPKAPK5 (PRAK) phosphorylates TP53 (p53) on serine residue S37, thereby activating it. MAPKAPK5-mediated phosphorylation of TP53 promotes growth arrest and senescence induced by oncogenic RAS, but is not needed for TP53-dependent growth arrest in response to DNA damage (Sun et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17254968	PRAK is essential for ras-induced senescence and tumor suppression Li, Y, Yamout, M, Sun, P, Frangou, CG, Yates, JR, Liao, R, Wright, PE, Yoshizuka, N, Deng, Q, Dong, MQ, Xie, C, Chen, J, Han, J, New, L, Moser, BA	Cell	2007