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p-T182-MAPKAPK5 [nucleoplasm]
Stable Identifier
R-HSA-3239018
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-T182-PRAK
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Active p38 MAPK phosphorylates MAPKAPK5 (Homo sapiens)
phospho-p38 MAPK:p-T-182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
p-T182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
MAPKAPK5 phosphorylates TP53 (Homo sapiens)
p-T182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
phospho-p38 MAPK:p-T-182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
p-T182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
MAPKAPK5 phosphorylates TP53 (Homo sapiens)
p-T182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
phospho-p38 MAPK:p-T-182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
p-T182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
p-S MAPK6,4 phosphorylate MAPKAPK5 (Homo sapiens)
p-S MAPK6,4:p-T182 MAKPAPK5 [nucleoplasm] (Homo sapiens)
p-T182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol (Homo sapiens)
p-S MAPK6,4:p-T182 MAKPAPK5 [nucleoplasm] (Homo sapiens)
p-T182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
p-T182 MAPKAPK5 phosphorylates FOXO1 (Homo sapiens)
p-T182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IW41 MAPKAPK5
Gene Names
MAPKAPK5, PRAK
Chain
chain:1-473
Reference Genes
BioGPS Gene:8550 MAPKAPK5
COSMIC (genes):MAPKAPK5 MAPKAPK5
CTD Gene:8550 MAPKAPK5
dbSNP Gene:8550 MAPKAPK5
ENSEMBL:ENSG00000089022 MAPKAPK5
HGNC:6889 MAPKAPK5
KEGG:hsa:8550 MAPKAPK5
Monarch:8550 MAPKAPK5
NCBI Gene:8550 MAPKAPK5
OMIM:606723 MAPKAPK5
UCSC:Q8IW41 MAPKAPK5
Reference Transcript
RefSeq:NM_139078.2 MAPKAPK5
RefSeq:NM_003668.3 MAPKAPK5
Participates
as a component of
p-S MAPK6,4:p-T182 MAKPAPK5 [nucleoplasm] (Homo sapiens)
phospho-p38 MAPK:p-T-182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-T182 MAPKAPK5 [cytosol]
p-S115 MAPKAPK5 [cytosol]
p-S115 MAPKAPK5 [nucleoplasm]
MAPKAPK5 [nucleoplasm]
Inferred To
phospho-p-T182-MAPKAPK5 [nucleoplasm]
(Gallus gallus)
phospho-p-T182-MAPKAPK5 [nucleoplasm]
(Mus musculus)
phospho-p-T182-MAPKAPK5 [nucleoplasm]
(Plasmodium falciparum)
Homologues of p-T182-MAPKAPK5 [nucleoplasm]
(Plasmodium falciparum)
phospho-Mapkapk5 [nucleoplasm]
(Rattus norvegicus)
phospho-mapkapk5 [nucleoplasm]
(Danio rerio)
phospho-MAPKAPK5 [nucleoplasm]
(Bos taurus)
phospho-MAPKAPK5 [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-threonine at 182
Coordinate
182
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
Guide to Pharmacology - Targets
2096
ENSEMBL
ENSP00000449381
,
ENSP00000449667
,
ENST00000550735
,
ENSG00000089022
,
ENST00000551404
OpenTargets
ENSG00000089022
ZINC - Substances
MAPK5_HUMAN
ZINC - Biogenic
MAPK5_HUMAN
ZINC target
Q8IW41
PRO
Q8IW41
ZINC - Investigational
MAPK5_HUMAN
GeneCards
MAPKAPK5
HPA
ENSG00000089022-MAPKAPK5
Pharos - Targets
Q8IW41
ZINC - Predictions - Purchasable
MAPK5_HUMAN
HMDB Protein
HMDBP01196
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16659 MAPK6 gene
6
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
MAPK6 [cytosol]
(R-HSA-5686979)
ub-MAPK6 [cytosol]
(R-HSA-5687000)
0.917
12
UniProt:Q15109 AGER
1
AGER [plasma membrane]
(R-HSA-197639)
0.655
6
UniProt:P31152 MAPK4
4
p-S186 MAPK4 [nucleoplasm]
(R-HSA-5687022)
p-S186 MAPK4 [cytosol]
(R-HSA-5687023)
MAPK4 [cytosol]
(R-HSA-5686973)
MAPK4 [nucleoplasm]
(R-HSA-5686975)
0.643
5
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