Active p38 MAPK phosphorylates MAPKAPK5

Stable Identifier
R-HSA-3239019
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
ReviewStatus
5/5
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Active p38 MAPK phosphorylates MAPKAPK5
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MAPK14 (p38 alpha) and MAPK11 (p38 beta) phosphorylate MAPKAPK5 (PRAK) on threonine residue 182, located in the conserved LMTP site in the T-loop of the kinase domain. Phosphorylation of T182 is necessary for the MAPKAPK5 catalytic activity (New et al. 1998).

Literature References
PubMed ID Title Journal Year
9628874 PRAK, a novel protein kinase regulated by the p38 MAP kinase

Kato, Y, Zhu, W, Han, J, Liu, K, Flood, LJ, Zhao, M, Jiang, Y, Parry, GC, New, L

EMBO J. 1998
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Catalyst Activity

protein serine/threonine kinase activity of phospho-p38 MAPK: MAPKAPK5 [nucleoplasm]

Physical Entity
phospho-p38 MAPK: MAPKAPK5 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Active p38 MAPK phosphorylates MAPKAPK5 (Bos taurus)
Active p38 MAPK phosphorylates MAPKAPK5 (Danio rerio)
Active p38 MAPK phosphorylates MAPKAPK5 (Gallus gallus)
Active p38 MAPK phosphorylates MAPKAPK5 (Mus musculus)
Active p38 MAPK phosphorylates MAPKAPK5 (Rattus norvegicus)
Active p38 MAPK phosphorylates MAPKAPK5 (Sus scrofa)
Active p38 MAPK phosphorylates MAPKAPK5 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-03-27)
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