Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SETD1A [nucleoplasm]
Stable Identifier
R-HSA-3239027
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone-lysine N-methyltransferase SETD1A, SET1A_HUMAN, KMT2F
Icon
Locations in the PathwayBrowser for interactor UniProt:P10242 MYB
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
Formation of WDR5-containing histone-modifying complexes (Homo sapiens)
Formation of the SET1A complex (Homo sapiens)
SETD1A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15047 SETD1A
Gene Names
SETD1A, KIAA0339, KMT2F, SET1, SET1A
Chain
chain:1-1707
Reference Genes
BioGPS Gene:9739 SETD1A
COSMIC (genes):SETD1A SETD1A
CTD Gene:9739 SETD1A
dbSNP Gene:9739 SETD1A
ENSEMBL:ENSG00000099381 SETD1A
HGNC:29010 SETD1A
KEGG:hsa:9739 SETD1A
Monarch:9739 SETD1A
NCBI Gene:9739 SETD1A
OMIM:611052 SETD1A
UCSC:O15047 SETD1A
Reference Transcript
RefSeq:XM_006721106.3 SETD1A
RefSeq:NM_014712.2 SETD1A
RefSeq:XM_005255723.1 SETD1A
RefSeq:XM_017023909.1 SETD1A
Other Identifiers
11720128_at
16818090
213202_PM_at
213202_at
3656683
3656684
3656685
3656686
3656687
3656688
3656689
3656690
3656691
3656693
3656694
3656695
3656696
3656697
3656698
3656699
3656700
3656701
3656702
3656703
3656704
3656705
3656706
3656707
3656708
3656709
3656710
3656712
3656713
3656714
3656717
3656718
3656719
3656720
3656721
3656722
3656723
3656724
3656725
3656726
3656727
3656728
3656729
3656730
3656731
3656732
3656733
3656734
3656735
3656736
3656738
41464_at
7994985
9739
A_14_P200428
A_23_P129678
A_33_P3234103
GE53066
GO:0000785
GO:0003676
GO:0003723
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0006325
GO:0006338
GO:0006974
GO:0007420
GO:0008013
GO:0008168
GO:0016607
GO:0016740
GO:0032259
GO:0035097
GO:0042800
GO:0043226
GO:0048188
GO:0048856
GO:0061629
GO:0140096
GO:0140945
GO:0140999
GO:1902036
GO:1902275
HMNXSV003010447
Hs.112078.0.S1_3p_at
ILMN_1714327
ILMN_1823208
PH_hs_0023573
TC16000364.hg
Participates
as an input of
Formation of the SET1A complex (Homo sapiens)
as a component of
SET1A complex [nucleoplasm] (Homo sapiens)
Inferred To
SETD1A [nucleoplasm]
(Bos taurus)
SETD1A [nucleoplasm]
(Caenorhabditis elegans)
SETD1A [nucleoplasm]
(Canis familiaris)
SETD1A [nucleoplasm]
(Dictyostelium discoideum)
SETD1A [nucleoplasm]
(Drosophila melanogaster)
SETD1A [nucleoplasm]
(Mus musculus)
SETD1A [nucleoplasm]
(Saccharomyces cerevisiae)
SETD1A [nucleoplasm]
(Schizosaccharomyces pombe)
SETD1A [nucleoplasm]
(Sus scrofa)
Setd1a [nucleoplasm]
(Rattus norvegicus)
Cross References
Guide to Pharmacology - Targets
2700
OpenTargets
ENSG00000099381
ENSEMBL
ENSP00000262519
,
ENSP00000518195
,
ENST00000262519
,
ENSP00000507683
,
ENST00000710314
,
ENST00000684162
IntEnz
2.1.1.364
HPA
ENSG00000099381-SETD1A
PRO
O15047
Pharos - Targets
O15047
Orphanet
SETD1A
GlyGen
O15047
HMDB Protein
HMDBP01734
PDB
3UVN
,
3S8S
,
8ILY
,
4EWR
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.837
7
UniProt:Q9P0U4 CXXC1
1
CXXC1 [nucleoplasm]
(R-HSA-535610)
0.69
6
UniProt:Q9UBL3 ASH2L
1
ASH2L [nucleoplasm]
(R-HSA-1629834)
0.69
4
UniProt:Q15291 RBBP5
1
RBBP5 [nucleoplasm]
(R-HSA-1629836)
0.662
5
UniProt:Q02248 Ctnnb1
14
Ctnnb1 [nucleoplasm]
(R-MMU-3451168)
Ctnnb1 [cytosol]
(R-MMU-448839)
Ctnnb1 [cytosol]
(R-MMU-202930)
Ctnnb1 [cytosol]
(R-MMU-202950)
Ctnnb1 [nucleoplasm]
(R-MMU-9735212)
Ctnnb1 [plasma membrane]
(R-MMU-9038440)
Ctnnb1 [plasma membrane]
(R-MMU-9761458)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942374)
beta-catenin [cytosol]
(R-MMU-206225)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942369)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942367)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942363)
phospho-Ctnnb1 [cytosol]
(R-MMU-3134933)
phospho-Ctnnb1 [nucleoplasm]
(R-MMU-3134926)
0.544
2
UniProt:P10242 MYB
1
MYB [nucleoplasm]
(R-HSA-992697)
0.536
2
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.532
4
UniProt:Q6UXN9 WDR82
1
WDR82 [nucleoplasm]
(R-HSA-9821474)
0.527
3
UniProt:O15294 OGT
2
OGT [nucleoplasm]
(R-HSA-3321845)
OGT [cytosol]
(R-HSA-9687814)
0.527
2
UniProt:P21741 MDK
1
MDK [extracellular region]
(R-HSA-2160953)
0.527
2
UniProt:Q9C005 DPY30
1
DPY30 [nucleoplasm]
(R-HSA-5669104)
0.527
2
UniProt:O43491 EPB41L2
1
EPB41L2 [cytosol]
(R-HSA-6797548)
0.527
2
UniProt:Q9Y5Z7 HCFC2
1
HCFC2 [nucleoplasm]
(R-HSA-9821232)
0.527
4
UniProt:P55345 ANM2
0.527
3
UniProt:Q9Y2J2 EPB41L3
1
EPB41L3 [cytosol]
(R-HSA-6797563)
0.527
2
UniProt:O00541 PES1
1
PES1 [nucleoplasm]
(R-HSA-6791207)
0.527
2
UniProt:Q5VWQ0 RSBN1
0.527
2
UniProt:P51610 HCFC1
2
K48polyUb,K63polyUb-HCFC1 [nucleoplasm]
(R-HSA-5690821)
HCFC1 [nucleoplasm]
(R-HSA-1592209)
0.499
2
UniProt:Q9UBL3-3 ASH2L
0.499
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text