In growing cells, the transcription of EZH2 methyltransferase gene, which codes for a subunit of the Polycomb repressor complex 2 (PRC2), is stimulated by E2F1, E2F2 and E2F3 that bind E2F sites in the EZH2 promoter. Direct binding to EZH2 promoter was directly experimentally examined and confirmed only for E2F3, while it was also demonstrated that E2F1-mediated stimulation of EZH2 gene transcription depends on the intact DNA-binding domain of E2F1. E2F4 also binds EZH2 promoter directly, with the strongest enrichment in G0, which is likely needed for repression of EZH2 transcription in non-growing cells (Bracken et al. 2003).