Viral DNA cleavage by TREX1

Stable Identifier
R-HSA-3245943
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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Viral DNA cleavage by TREX1
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TREX1 digests unpaired nucleotides on ssDNA and dsDNA ends through a 3' to 5' exonuclease activity (Perrino FW et al. 1994; de Silva U et al. 2007; Lehtinen DA et al. 2008; Fye JM et al 2011). Upon viral infection the TREX1-deficient human and mouse cells were found to be more resistant to different types of RNA viruses, suggesting that TREX1 activity may inhibit the host innate immune responses by clearing viral DNA generated during reverse transcription (Yan N et al. 2010; Hasan M et al. 2012).
Literature References
PubMed ID Title Journal Year
20871604 The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

Lieberman, J, Yan, N, Regalado-Magdos, AD, Lee-Kirsch, MA, Stiggelbout, B

Nat. Immunol. 2010
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Catalyst Activity

3'-5' exonuclease activity of TREX1:viral DNA [endoplasmic reticulum membrane]

Physical Entity
TREX1:viral DNA [endoplasmic reticulum membrane] (Homo sapiens)
Activity
3'-5' exonuclease activity (GO:0008408)
Authored
Shamovsky, V  (2013-02-06)
Reviewed
Wu, J  (2013-05-22)
Jin, L  (2013-05-22)
D'Eustachio, P  (2013-02-11)
Created
Shamovsky, V  (2013-03-28)
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