WNT ligands traffic to the plasma membrane

Stable Identifier
R-HSA-3247844
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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WLS accompanies WNT through the secretory pathway to the cell surface, where the ligand is released into the extracellular space (Bänziger et al, 2006; Bartscherer et al, 2006; Goodman et al, 2006).
Literature References
PubMed ID Title Journal Year
16678096 Secretion of Wnt ligands requires Evi, a conserved transmembrane protein

Bartscherer, K, Boutros, M, Pelte, N, Ingelfinger, D

Cell 2006
17108000 Sprinter: a novel transmembrane protein required for Wg secretion and signaling

Firtina, Z, Spana, EP, Betts, D, Thombre, S, Selva, EM, Goodman, RM, Roebuck, J, Gray, D

Development 2006
16678095 Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells

Zipperlen, P, Soldini, D, Bänziger, C, Hausmann, G, Schütt, C, Basler, K

Cell 2006
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