DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1

Stable Identifier
R-HSA-3249386
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1
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NLRP4 regulate the host immune responses by recruiting E3 ubiquitin-protein ligase DTX4 to the kinase TBK1. DTX4 promotes K48-linked ubiquitination of TBK1 resulting in the degradation of TBK1 and downregulation of IFN signaling (Cui J et al. 2012).

Literature References
PubMed ID Title Journal Year
22388039 NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4

Wang, HY, Cui, J, Songyang, Z, Li, Y, Wang, RF, Liu, D, Zhu, L

Nat. Immunol. 2012
Participants
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Output
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as an event of
Catalyst Activity

ubiquitin-protein transferase activity of NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol]

Physical Entity
NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Authored
Shamovsky, V  (2013-02-06)
Reviewed
Wu, J  (2013-05-22)
Jin, L  (2013-05-22)
D'Eustachio, P  (2013-02-11)
Created
Shamovsky, V  (2013-04-09)
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