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CAPNS1 [cytosol]
Stable Identifier
R-HSA-3288229
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Calpain small subunit 1, CPNS1_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
Cytoplasmic proteases cleave Profilaggrin producing Filaggrin (Homo sapiens)
Cytoplasmic profilaggrin processing proteases [cytosol] (Homo sapiens)
Calpain1 [cytosol] (Homo sapiens)
CAPNS1 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
Calpain activation (Homo sapiens)
Calpain1,Calpain2 [cytosol] (Homo sapiens)
Calpain1 [cytosol] (Homo sapiens)
CAPNS [cytosol] (Homo sapiens)
CAPNS1 [cytosol] (Homo sapiens)
Calpain2 [cytosol] (Homo sapiens)
CAPNS [cytosol] (Homo sapiens)
CAPNS1 [cytosol] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Homo sapiens)
CAPN:4xCa2+:CAPNS [cytosol] (Homo sapiens)
CAPNS [cytosol] (Homo sapiens)
CAPNS1 [cytosol] (Homo sapiens)
E-cadherin degradation by caspase-3 and calpain-1 (Homo sapiens)
Active caspase-3 heterotetramer, calpain-1 [cytosol] (Homo sapiens)
Calpain1 [cytosol] (Homo sapiens)
CAPNS1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04632 CAPNS1
Gene Names
CAPNS1, CAPN4, CAPNS
Chain
chain:1-268
Reference Genes
BioGPS Gene:826 CAPNS1
COSMIC (genes):CAPNS1 CAPNS1
CTD Gene:826 CAPNS1
dbSNP Gene:826 CAPNS1
ENSEMBL:ENSG00000126247 CAPNS1
ENSEMBL:ENSG00000126247.11 CAPNS1
HGNC:1481 CAPNS1
KEGG Gene (Homo sapiens):826 CAPNS1
Monarch:826 CAPNS1
NCBI Gene:826 CAPNS1
OMIM:114170 CAPNS1
UCSC:P04632 CAPNS1
Reference Transcript
RefSeq:NM_001003962.2 CAPNS1
RefSeq:XM_005259295.1 CAPNS1
RefSeq:NM_001749.3 CAPNS1
RefSeq:NM_001302632.1 CAPNS1
RefSeq:XM_005259296.1 CAPNS1
RefSeq:NM_001302633.1 CAPNS1
Other Identifiers
11758205_x_at
11758295_at
16652937
16861380
18671221
18671222
18671223
18671224
18671225
18671226
18671227
18671228
18671229
200001_PM_at
200001_at
36138_at
3831169
3831170
3831173
3831176
3831177
3831178
3831179
3831183
3831184
3831185
3831186
3831190
3831192
3831193
3831194
3831195
3831196
3831197
7893173
7893539
7893544
7893740
7894512
7894542
7894761
7895873
7895903
7895928
7896030
7896258
7896370
7896533
8028172
826
A_23_P67648
GE62015
GO:0003824
GO:0004198
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0005886
GO:0006508
GO:0006914
GO:0008284
GO:0016020
GO:0016241
GO:0016787
GO:0043226
GO:0046872
GO:0070062
GO:0110158
GO:0140096
HMNXSV003018689
HMNXSV003044471
ILMN_1655418
PH_hs_0024468
PH_hs_0033087
TC19000496.hg
X04106_at
g4502564_3p_s_at
Participates
as a member of
CAPNS [cytosol] (Homo sapiens)
as a component of
Calpain1 [cytosol] (Homo sapiens)
Other forms of this molecule
CAPNS1 [plasma membrane]
Inferred To
capns2 [cytosol]
(Xenopus tropicalis)
capns1 [cytosol]
(Danio rerio)
CAPNS1 [cytosol]
(Bos taurus)
CAPNS1 [cytosol]
(Canis familiaris)
CAPNS1 [cytosol]
(Mus musculus)
CAPNS1 [cytosol]
(Rattus norvegicus)
CAPNS1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001003962.1
,
XP_005259352.1
,
NP_001289561.1
,
XP_005259353.1
,
NP_001740.1
,
NP_001289562.1
OpenTargets
ENSG00000126247
GeneCards
P04632
HPA
ENSG00000126247-CAPNS1
Ensembl
ENST00000246533
,
ENST00000588815
,
ENSP00000246533
,
ENSP00000464849
,
ENSG00000126247
PRO
P04632
Pharos - Targets
P04632
HMDB Protein
HMDBP07628
PDB
6QLB
,
4WQ3
,
1KFU
,
4PHK
,
1KFX
,
4WQ2
,
4PHJ
,
5D69
,
4PHM
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.527
4
UniProt:P20936 RASA1
1
RASA1 [cytosol]
(R-HSA-186833)
0.524
3
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