Reactome | TRPM4,5 transport extracellular Na+ to cytosol

TRPM4,5 transport extracellular Na+ to cytosol

Stable Identifier

R-HSA-3295580

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

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TRPM4,5 transport extracellular Na+ to cytosol

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Most members of the TRP channel family are permeable to Ca2+. Although TRPM4 and 5 can be activated by increased levels of intracellular Ca2+, they are impermeable to it. Instead, they are monovalent-selective with highest affinity for Na+ transport, of which leads to depolarization of the membrane (Launay et al. 2002, Prawitt et al. 2003). They play a central role in cardiomyocytes, neurons, endocrine pancreas cells, kidney epithelial cells and cochlea hair cells.

Literature References

PubMed ID	Title	Journal	Year
12015988	TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization Kinet, JP, Fleig, A, Perraud, AL, Penner, R, Launay, P, Scharenberg, AM	Cell	2002
14634208	TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i Fleig, A, Penner, R, Monteilh-Zoller, MK, Spangenberg, C, Zabel, B, Prawitt, D, Brixel, L	Proc. Natl. Acad. Sci. U.S.A.	2003