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HCAR1 [plasma membrane]
Stable Identifier
R-HSA-3296280
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Hydroxycarboxylic acid receptor 1, HCAR1_HUMAN, GPR81
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR1:LACT [plasma membrane] (Homo sapiens)
HCAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR1:LACT [plasma membrane] (Homo sapiens)
HCAR1 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR1:LACT [plasma membrane] (Homo sapiens)
HCAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR1:LACT [plasma membrane] (Homo sapiens)
HCAR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR1:LACT [plasma membrane] (Homo sapiens)
HCAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR1:LACT [plasma membrane] (Homo sapiens)
HCAR1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Hydroxycarboxylic acid-binding receptors (Homo sapiens)
HCAR1 binds LACT (Homo sapiens)
HCAR1 [plasma membrane] (Homo sapiens)
HCAR1:LACT [plasma membrane] (Homo sapiens)
HCAR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BXC0 HCAR1
Gene Names
HCAR1, GPR104, GPR81, HCA1, FKSG80
Chain
chain:1-346
Reference Genes
BioGPS Gene:27198 HCAR1
COSMIC (genes):HCAR1 HCAR1
CTD Gene:27198 HCAR1
dbSNP Gene:27198 HCAR1
ENSEMBL:ENSG00000196917 HCAR1
HGNC:4532 HCAR1
KEGG:hsa:27198 HCAR1
Monarch:27198 HCAR1
NCBI Gene:27198 HCAR1
OMIM:606923 HCAR1
UCSC:Q9BXC0 HCAR1
Reference Transcript
RefSeq:NM_032554.3 HCAR1
Other Identifiers
11731079_s_at
11731080_at
11750278_s_at
16771787
224131_PM_at
224131_at
27198
3475775
3475776
3475777
3475778
3475779
3475780
3475781
41934_at
7967325
A_23_P394246
A_33_P3380472
GE62307
GO:0004930
GO:0005886
GO:0007186
GO:0016020
GO:0050995
GO:0060089
HMNXSV003001969
ILMN_1811272
ILMN_2161848
PH_hs_0023797
TC12002077.hg
g13517963_3p_at
p3420
Participates
as an input of
HCAR1 binds LACT (Homo sapiens)
as a component of
HCAR1:LACT [plasma membrane] (Homo sapiens)
Inferred To
Hcar1 [plasma membrane]
(Mus musculus)
Hcar1 [plasma membrane]
(Rattus norvegicus)
hcar1-4 [plasma membrane]
(Danio rerio)
gpr81 [plasma membrane]
(Bos taurus)
gpr81 [plasma membrane]
(Canis familiaris)
gpr81 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_115943.1
Guide to Pharmacology - Targets
311
ENSEMBL
ENST00000432564
,
ENSP00000389255
OpenTargets
ENSG00000196917
HPA
ENSG00000196917-HCAR1
ZINC - Substances
HCAR1_HUMAN
ZINC target
Q9BXC0
PRO
Q9BXC0
Pharos - Targets
Q9BXC0
GlyGen
Q9BXC0
ZINC - Predictions - Purchasable
HCAR1_HUMAN
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