Reactome | TCF7 [nucleoplasm]

TCF7 [nucleoplasm]

Stable Identifier

R-HSA-3299543

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

TCF1

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX3 (Homo sapiens)
      - RUNX3 regulates WNT signaling (Homo sapiens)
        
        RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) (Homo sapiens)
        
        CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Homo sapiens)
        
        TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Homo sapiens)
        
        TCF7 [nucleoplasm] (Homo sapiens)
        
        RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Homo sapiens)
        
        CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Homo sapiens)
        
        TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm] (Homo sapiens)
        
        TCF7 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P36402 TCF7

Gene Names

TCF7, TCF1

Chain

chain:1-384

Reference Genes

BioGPS Gene:6932 TCF7

COSMIC (genes):TCF7 TCF7

CTD Gene:6932 TCF7

dbSNP Gene:6932 TCF7

ENSEMBL:ENSG00000081059 TCF7

HGNC:11639 TCF7

KEGG:hsa:6932 TCF7

Monarch:6932 TCF7

NCBI Gene:6932 TCF7

OMIM:189908 TCF7

UCSC:P36402 TCF7

Reference Transcript

Other Identifiers

11727561_x_at

11736473_a_at

11736474_s_at

11736475_x_at

11755180_x_at

11755351_a_at

16989202

205254_PM_x_at

205254_x_at

205255_PM_x_at

205255_x_at

2829190

2829191

2829192

2829193

2829194

2829195

2829196

2829197

2829198

2829199

2829200

2829213

2829214

2829215

2829216

2829217

2829218

2829219

2829220

2829221

2829222

2829223

2829224

2829225

2829226

2829227

2829228

2829229

2829230

2829231

2829232

2829233

2829234

2829235

2829236

2829239

2829242

31440_at

32649_at

6932

8108050

A_14_P113835

A_14_P118942

A_14_P130186

A_23_P7582

A_33_P3250671

GE59854

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0001217

GO:0002376

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0006355

GO:0006357

GO:0006955

GO:0008013

GO:0016055

GO:0016604

GO:0030154

GO:0042492

GO:0043226

GO:0045586

GO:0045892

GO:0060070

GO:0071353

GO:0140110

GO:1990837

GO:1990907

HMNXSV003042272

HMNXSV003049361

Hs.169294.0.S1_3p_s_at

ILMN_1676470

ILMN_1677846

ILMN_1683986

ILMN_1707005

ILMN_1710746

ILMN_2367141

PH_hs_0010094

TC05000657.hg

TC05002628.hg

X59871_at

g4507402_3p_a_at

Participates

as a member of

as a candidate of

Inferred To

tcf7 [nucleoplasm] (Danio rerio)

pan [nucleoplasm] (Drosophila melanogaster)

Tcf7 [nucleoplasm] (Mus musculus)

Tcf7 [nucleoplasm] (Rattus norvegicus)

TCF7 [nucleoplasm] (Bos taurus)

TCF7 [nucleoplasm] (Canis familiaris)

TCF7 [nucleoplasm] (Gallus gallus)

TCF7 [nucleoplasm] (Sus scrofa)

pop-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

XP_006714747.1, NP_998813.1, NP_003193.2, NP_001333354.1, NP_001333379.1, NP_001128323.2, NP_963963.1, NP_963965.1

ENSEMBL

ENST00000518915, ENSP00000340347, ENSP00000430179, ENST00000378560, ENST00000520958, ENST00000342854, ENST00000395023, ENSP00000367822, ENSP00000378469, ENSP00000429547

OpenTargets

ENSG00000081059

HPA

ENSG00000081059-TCF7

PRO

P36402

Pharos - Targets

P36402

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.779	4

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