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TCF/LEF [nucleoplasm]
Stable Identifier
R-HSA-3299546
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
TCF/LEF:CTNNB1 bind canonical WNT target promoters (Homo sapiens)
'canonical' WNT target genes:TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
Transcription of canonical WNT targets is negatively regulated by NLK-dependent phosphorylation of TCF/LEF (Homo sapiens)
'canonical' WNT target genes:TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
Repression of WNT target genes (Homo sapiens)
TCF/LEF binds WNT promoters (Homo sapiens)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
TLE recruits HDAC1 to WNT promoters (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm] (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
TLE tetramers bind TCF/LEF at WNT promoters (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes (Homo sapiens)
'canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm] (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
TCF:Beta-catenin binds SOX proteins (Homo sapiens)
TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:SOX4,SOX13,SOX17 [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
beta-catenin is replaced by repression complexes at the promoter (Homo sapiens)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Homo sapiens)
TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
Beta-catenin recruits CBP/p300 (Homo sapiens)
TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:CBP/p300 [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
Beta-catenin recruits CDC73 and LEO1 (Homo sapiens)
TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:PAF1-like complex [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
Beta-catenin recruits SMARCA4 (Homo sapiens)
TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:SMARCA4:TERT [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
Beta-catenin recruits TRRAP/KAT5 HAT components (Homo sapiens)
TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
Beta-catenin:TCF associates with BCL9 and PYGO (Homo sapiens)
TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
KAT5 HAT complex acetylates TCF4 gene at histone H4 (Homo sapiens)
TCF/LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
Recruitment of SET1 methyltransferase complex (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Homo sapiens)
TCF/LEF [nucleoplasm] (Homo sapiens)
Participants
members
TCF7L2 [nucleoplasm]
(Homo sapiens)
LEF1 [nucleoplasm]
(Homo sapiens)
candidates
TCF7 [nucleoplasm]
(Homo sapiens)
TCF7L1 [nucleoplasm]
(Homo sapiens)
Participates
as an input of
TCF/LEF binds WNT promoters (Homo sapiens)
as a component of
'canonical' WNT target genes:TCF/LEF [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1 [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm] (Homo sapiens)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Homo sapiens)
Inferred To
pan [nucleoplasm]
(Drosophila melanogaster)
TCF/LEF [nucleoplasm]
(Bos taurus)
TCF/LEF [nucleoplasm]
(Canis familiaris)
TCF/LEF [nucleoplasm]
(Danio rerio)
TCF/LEF [nucleoplasm]
(Gallus gallus)
TCF/LEF [nucleoplasm]
(Mus musculus)
TCF/LEF [nucleoplasm]
(Rattus norvegicus)
TCF/LEF [nucleoplasm]
(Sus scrofa)
TCF/LEF [nucleoplasm]
(Xenopus tropicalis)
pop-1 [nucleoplasm]
(Caenorhabditis elegans)
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