Reactome | TAS2R38 [plasma membrane]

TAS2R38 [plasma membrane]

Stable Identifier

R-HSA-3299607

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Taste receptor type 2 member 38, T2R38_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R38 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R38 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R38 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R38 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R38 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R38 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - T2Rs bind bitter-tasting compounds (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R38 [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R38 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P59533 TAS2R38

Gene Names

TAS2R38, PTC

Chain

chain:1-333

Reference Genes

BioGPS Gene:5726 TAS2R38

COSMIC (genes):TAS2R38 TAS2R38

CTD Gene:5726 TAS2R38

dbSNP Gene:5726 TAS2R38

ENSEMBL:ENSG00000257138 TAS2R38

ENSEMBL_homo_sapiens_GENE:ENSG00000257138.1 TAS2R38

HGNC:9584 TAS2R38

KEGG Gene (Homo sapiens):5726 TAS2R38

Monarch:5726 TAS2R38

NCBI Gene:5726 TAS2R38

OMIM:607751 TAS2R38

UCSC:P59533 TAS2R38

Reference Transcript

RefSeq:NM_176817.4 TAS2R38

Other Identifiers

11735975_at

1553555_PM_at

1553555_at

17063734

3076883

3076884

3076885

3076886

5726

8143482

A_23_P359746

GO:0001580

GO:0004930

GO:0005886

GO:0007165

GO:0007186

GO:0016020

GO:0023052

GO:0033038

GO:0050877

GO:0050896

GO:0050909

GO:0060089

HMNXSV003046882

Hs2Affx.1.31.S1_3p_at

ILMN_1751637

PH_hs_0026498

TC07001935.hg

Participates

as a member of

as a component of

TAS2R38:ligand [plasma membrane] (Homo sapiens)

Inferred To

t2r14 [plasma membrane] (Xenopus tropicalis)

t2r2 [plasma membrane] (Xenopus tropicalis)

Homologues of TAS2R38 [plasma membrane] (Danio rerio)

Homologues of TAS2R38 [plasma membrane] (Gallus gallus)

Homologues of TAS2R38 [plasma membrane] (Xenopus tropicalis)

tas2r1a [plasma membrane] (Danio rerio)

TAS2R1b [plasma membrane] (Danio rerio)

t2r3 [plasma membrane] (Xenopus tropicalis)

TAS2R7 [plasma membrane] (Gallus gallus)

TAS2R38 [plasma membrane] (Bos taurus)

TAS2R38 [plasma membrane] (Canis familiaris)

T2r38 [plasma membrane] (Rattus norvegicus)

Tas2r38 [plasma membrane] (Mus musculus)

tas2r7 [plasma membrane] (Xenopus tropicalis)

TAS2R40 [plasma membrane] (Gallus gallus)

t2r15 [plasma membrane] (Xenopus tropicalis)

tas2r4 [plasma membrane] (Xenopus tropicalis)

LOC101747503 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_789787.4

Guide to Pharmacology - Targets

682

OpenTargets

ENSG00000257138

GeneCards

P59533

HPA

ENSG00000257138-TAS2R38

Ensembl

ENST00000547270, ENSP00000448219, ENSG00000257138

PRO

P59533

Pharos - Targets

P59533