Reactome | TAS2R4 [plasma membrane]

TAS2R4 [plasma membrane]

Stable Identifier

R-HSA-3299613

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Taste receptor type 2 member 4, TA2R4_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R4 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R4 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R4 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - T2Rs bind bitter-tasting compounds (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R4 [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NYW5 TAS2R4

Gene Names

TAS2R4

Chain

chain:1-299

Reference Genes

BioGPS Gene:50832 TAS2R4

COSMIC (genes):TAS2R4 TAS2R4

CTD Gene:50832 TAS2R4

dbSNP Gene:50832 TAS2R4

ENSEMBL:ENSG00000127364 TAS2R4

ENSEMBL_homo_sapiens_GENE:ENSG00000127364.4 TAS2R4

HGNC:14911 TAS2R4

KEGG Gene (Homo sapiens):50832 TAS2R4

Monarch:50832 TAS2R4

NCBI Gene:50832 TAS2R4

OMIM:604869 TAS2R4

UCSC:Q9NYW5 TAS2R4

Reference Transcript

RefSeq:NM_016944.1 TAS2R4

Other Identifiers

11737668_at

17052417

221392_PM_at

221392_at

3027955

3027957

3027958

3027959

3027960

50832

8136645

ADDON002529.hg

A_14_P134356

A_23_P20101

GE79701

GO:0001580

GO:0004930

GO:0005886

GO:0005929

GO:0007165

GO:0007186

GO:0007585

GO:0008527

GO:0016020

GO:0023052

GO:0033038

GO:0042995

GO:0043226

GO:0050877

GO:0050896

GO:0050909

GO:0060089

GO:0060170

HMNXSV003052058

ILMN_1745038

PH_hs_0026760

PH_hs_0036120

TC07000894.hg

g8394401_3p_at

Participates

as a member of

as a component of

TAS2R4:ligand [plasma membrane] (Homo sapiens)

Inferred To

TAS2R4 [plasma membrane] (Bos taurus)

TAS2R4 [plasma membrane] (Canis familiaris)

TAS2R4 [plasma membrane] (Sus scrofa)

t2r14 [plasma membrane] (Xenopus tropicalis)

t2r2 [plasma membrane] (Xenopus tropicalis)

Tas2r4 [plasma membrane] (Mus musculus)

Tas2r4 [plasma membrane] (Rattus norvegicus)

tas2r1a [plasma membrane] (Danio rerio)

Homologues of TAS2R19 [plasma membrane] (Danio rerio)

Homologues of TAS2R19 [plasma membrane] (Gallus gallus)

Homologues of TAS2R19 [plasma membrane] (Xenopus tropicalis)

TAS2R1b [plasma membrane] (Danio rerio)

t2r3 [plasma membrane] (Xenopus tropicalis)

TAS2R7 [plasma membrane] (Gallus gallus)

tas2r7 [plasma membrane] (Xenopus tropicalis)

TAS2R40 [plasma membrane] (Gallus gallus)

t2r15 [plasma membrane] (Xenopus tropicalis)

tas2r4 [plasma membrane] (Xenopus tropicalis)

LOC101747503 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_058640.1

Guide to Pharmacology - Targets

661

OpenTargets

ENSG00000127364

GeneCards

Q9NYW5

HPA

ENSG00000127364-TAS2R4

ZINC target

Q9NYW5

Ensembl

ENST00000247881, ENSG00000127364, ENSP00000247881

PRO

Q9NYW5

Pharos - Targets

Q9NYW5

HMDB Protein

HMDBP08042