Reactome | TAS2R41 [plasma membrane]

TAS2R41 [plasma membrane]

Stable Identifier

R-HSA-3299622

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Taste receptor type 2 member 41, T2R41_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R41 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R41 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R41 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R41 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R41 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R41 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - T2Rs bind bitter-tasting compounds (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R41 [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R41 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P59536 TAS2R41

Gene Names

TAS2R41

Chain

chain:1-307

Reference Genes

BioGPS Gene:259287 TAS2R41

COSMIC (genes):TAS2R41 TAS2R41

CTD Gene:259287 TAS2R41

dbSNP Gene:259287 TAS2R41

ENSEMBL:ENSG00000221855 TAS2R41

ENSEMBL_homo_sapiens_GENE:ENSG00000221855.1 TAS2R41

ENSEMBL_homo_sapiens_GENE:ENSG00000284982.1 TAS2R41

HGNC:18883 TAS2R41

KEGG Gene (Homo sapiens):259287 TAS2R41

Monarch:259287 TAS2R41

NCBI Gene:259287 TAS2R41

OMIM:613965 TAS2R41

UCSC:P59536 TAS2R41

Reference Transcript

RefSeq:NM_176883.2 TAS2R41

Other Identifiers

11735985_at

1553558_PM_at

1553558_at

17052850

259287

3029214

3029215

3029216

8136934

A_14_P119806

A_23_P337867

GE520324

GO:0004930

GO:0005515

GO:0005886

GO:0007165

GO:0007186

GO:0016020

GO:0023052

GO:0050877

GO:0050896

GO:0050909

GO:0060089

HMNXSV003046494

Hs2Affx.1.36.S1_3p_at

PH_hs_0026208

TC07000938.hg

Participates

as a member of

as a component of

TAS2R41:ligand [plasma membrane] (Homo sapiens)

Inferred To

t2r14 [plasma membrane] (Xenopus tropicalis)

t2r2 [plasma membrane] (Xenopus tropicalis)

Homologues of TAS2R10 [plasma membrane] (Danio rerio)

Homologues of TAS2R10 [plasma membrane] (Gallus gallus)

Homologues of TAS2R10 [plasma membrane] (Xenopus tropicalis)

t2r3 [plasma membrane] (Xenopus tropicalis)

TAS2R7 [plasma membrane] (Gallus gallus)

TAS2R41 [plasma membrane] (Canis familiaris)

TAS2R41 [plasma membrane] (Sus scrofa)

Tas2r41 [plasma membrane] (Mus musculus)

Tas2r41 [plasma membrane] (Rattus norvegicus)

tas2r200.1 [plasma membrane] (Danio rerio)

tas2r7 [plasma membrane] (Xenopus tropicalis)

TAS2R40 [plasma membrane] (Gallus gallus)

t2r15 [plasma membrane] (Xenopus tropicalis)

tas2r4 [plasma membrane] (Xenopus tropicalis)

tas2r200.2 [plasma membrane] (Danio rerio)

LOC101747503 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_795364.2

Guide to Pharmacology - Targets

680

OpenTargets

ENSG00000221855

GeneCards

P59536

HPA

ENSG00000221855-TAS2R41

Ensembl

ENSG00000284982, ENSP00000386201, ENSP00000494656, ENST00000408916, ENST00000646750, ENSG00000221855

ZINC target

P59536

PRO

P59536

Pharos - Targets

P59536

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60493 SNX3	3	SNX3 [cytosol] (R-HSA-3247743) PolyUb-SNX3 [endosome membrane] (R-HSA-6782993) SNX3 [endosome membrane] (R-HSA-6782991)	0.527	2
UniProt:O15498 YKT6	5	PalmC-YKT6 [endoplasmic reticulum membrane] (R-HSA-5688145) PalmC-YKT6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688558) PalmC-YKT6 [ER to Golgi transport vesicle membrane] (R-HSA-5688557) PalmC-YKT6 [Golgi membrane] (R-HSA-6808792) PalmC-YKT6 [transport vesicle] (R-HSA-6808794)	0.527	2
UniProt:Q14353 GAMT	1	GAMT [cytosol] (R-HSA-71276)	0.527	2